est.nca: Estimates individual NCA metrics from concentration vs time data. data.

Description

est.nca estimates a comprehensive set of NCA metrics for a given individual using concentration vs time profile.

Usage

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est.nca(time, conc, backExtrp = FALSE, negConcExcl = FALSE,
  doseType = "ns", adminType = "extravascular", doseAmt = NULL,
  method = "linear-log", AUCTimeRange = NULL, LambdaTimeRange = NULL,
  LambdaExclude = NULL, doseTime = doseTime, Tau = NULL, TI = NULL,
  simFile = NULL, dset = "obs")

Arguments

time

Numeric array for time

conc

Numeric array for concentration

backExtrp

If back-extrapolation is needed for AUC (TRUE or FALSE) (FALSE)

negConcExcl

Exclude -ve conc (FALSE)

doseType

Steady-state (ss) or nonsteady-state (ns) dose ("ns")

adminType

Route of administration (iv-bolus,iv-infusion,extravascular) ("extravascular")

doseAmt

Dose amounts ("NULL")

method

linear, log or linear-log ("linear-log")

AUCTimeRange

User-defined window of time used to estimate AUC ("NULL")

LambdaTimeRange

User-defined window of time to estimate elimination rate-constant ("NULL")

LambdaExclude

User-defined excluded observation time points for estimation of elimination rate-constant ("NULL")

doseTime

Dose time prior to the first observation for steady-state data (NULL)

Tau

Dosing interval for steady-state data ("NULL")

TI

Infusion duration ("NULL")

simFile

Name of the simulated concentration-time data if present ("NULL")

dset

Type, i.e., observed or simulated concentration-time data set ("obs" or "sim") ("obs")

Details

est.nca estimates a comprehensive set of NCA metrics using the concentration-time profile of an individual. NCA metrics are eatimated according to traditional PK calculations. The names of the various NCA metrics estimated in this package are assigned mainly following the names used in WinNonlin. This package accepts any of the three different types of drug administration, (i) iv-bolus, (ii) iv-infusion and (iii) extravascular; ncappc also can accept both non-steady state and steady-state data. The NCA metrics that are estimated and reported by ncappc are listed below.

Value

An array of estimated NCA metrics


Questions? Problems? Suggestions? or email at ian@mutexlabs.com.

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