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RDmn = function(d0, conf.level=0.95, eps=1e-8)
{
y1 = d0[, "y1"]
n1 = d0[, "n1"]
y2 = d0[, "y2"]
n2 = d0[, "n2"]
if (any(c(y1, n1 - y1, y2, n2 - y2) < 0) | any(n1*n2 == 0)) stop("Check the input!")
if (any(n1 > 1/eps) | any(n2 > 1/eps)) stop("Too large n1 or n2!")
Res1 = RDmn1(y1[1], n1[1], y2[1], n2[1], conf.level=conf.level)
rownames(Res1) = NULL
nr = nrow(d0)
if (nr == 1) return(Res1)
v0 = qchisq(conf.level, 1)
p1 = y1/n1
p2 = y2/n2
p1p2rd = function(rd) {
L3 = n1 + n2
L2 = (n1 + 2*n2)*rd - L3 - y1 - y2
L1 = (n2*rd - L3 - 2*y2)*rd + y1 + y2
L0 = y2*rd*(1 - rd)
q = L2^3/(3*L3)^3 - L1*L2/(6*L3^2) + L0/(2*L3) # eq 28
p = sign(q)*sqrt(max(0, L2^2/(3*L3)^2 - L1/(3*L3)))
a = (pi + ifelse(p == 0, acos(0), acos(min(1, max(-1, q/p^3)))))/3
p2 = 2*p*cos(a) - L2/(3*L3)
return(cbind(p1 = p2 + rd, p2))
}
wrd = function(rd, MaxIter=50) {
pw = n1*n2/(n1 + n2)
for (i in 1:MaxIter) {
p = p1p2rd(rd)
w = pw/sum(pw)
r1 = sum(w*p[, 1])
r2 = sum(w*p[, 2])
w = 1/(r1*(1 - r1)/(r2*(1 - r2))/n1 + 1/n2)
if (sum(abs(w - pw)) < 1e-8) break
pw = w
}
return(w)
}
w = n1*n2/(n1 + n2) # MH weight for initial guess
pRD = sum(w/sum(w)*(p1 - p2)) # initial guess with MH weight
for (i in 1:50) {
w2 = wrd(pRD)
fRD = sum(w2/sum(w2)*(p1 - p2))
if (abs(fRD - pRD) < eps) break
pRD = fRD
}
Obj = function(rd) {
p = p1p2rd(rd)
p1 = p[, 1]
p2 = p[, 2]
v = (p1*(1 - p1)/n1 + p2*(1 - p2)/n2)*(n1 + n2)/(n1 + n2 - 1)
v[v < 0] = 0
w = wrd(rd)
return(sum(w*(rd - fRD))^2/sum(w*w*v) - v0) # for uniroot
}
options(warn=-1)
if (fRD < -1 + eps) { lower = -1
} else { lower = uniroot(Obj, c(max(-1, fRD - 1) + eps, fRD - eps))$root }
if (fRD > 1 - eps) { upper = 1
} else { upper = uniroot(Obj, c(fRD + eps, 1 - eps))$root }
options(warn=0)
for (i in 2:nr) {
Res1 = rbind(Res1, RDmn1(y1[i], n1[i], y2[i], n2[i], conf.level=conf.level))
}
rownames(Res1) = rownames(d0)
p1s = sum(w2/sum(w2)*p1)
p2s = sum(w2/sum(w2)*p2)
Res2 = c(p1=p1s, p2=p2s, RD=fRD, lower=lower, upper=upper)
Res1 = list(Strata=Res1, Common=Res2)
return(Res1)
}
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