1-mer substitution model of somatic hypermutation based on analysis of silent mutations in functional heavy chain Ig sequences from Homo sapiens.
A 4x4 matrix of nucleotide substitution rates. The rates are normalized, therefore each row sums up to 1.
HS1FDistance in versions of SHazaM prior to 0.1.5.
Yaari G, et al. Models of somatic hypermutation targeting and substitution based on synonymous mutations from high-throughput immunoglobulin sequencing data. Front Immunol. 2013 4(November):358.
See HKL_S1F for the human light chain 1-mer substitution model and MK_RS1NF for the mouse light chain 1-mer substitution model.
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