HH_S1F: Human heavy chain, silent, 1-mer, functional substitution...

Description Usage Format Note References See Also


1-mer substitution model of somatic hypermutation based on analysis of silent mutations in functional heavy chain Ig sequences from Homo sapiens.




A 4x4 matrix of nucleotide substitution rates. The rates are normalized, therefore each row sums up to 1.


HH_S1F replaces HS1FDistance in versions of SHazaM prior to 0.1.5.


  1. Yaari G, et al. Models of somatic hypermutation targeting and substitution based on synonymous mutations from high-throughput immunoglobulin sequencing data. Front Immunol. 2013 4(November):358.

See Also

See HKL_S1F for the human light chain 1-mer substitution model and MK_RS1NF for the mouse light chain 1-mer substitution model.

shazam documentation built on July 9, 2021, 1:07 a.m.