HH_S1F | R Documentation |
1-mer substitution model of somatic hypermutation based on analysis of silent mutations in functional heavy chain Ig sequences from Homo sapiens.
HH_S1F
A 4x4 matrix of nucleotide substitution rates. The rates are normalized, therefore each row sums up to 1.
HH_S1F
replaces HS1FDistance
in versions of SHazaM prior to 0.1.5.
Yaari G, et al. Models of somatic hypermutation targeting and substitution based on synonymous mutations from high-throughput immunoglobulin sequencing data. Front Immunol. 2013 4(November):358.
See HKL_S1F for the human light chain 1-mer substitution model and MK_RS1NF for the mouse light chain 1-mer substitution model.
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