signatures: Sample concentration-response data set from HTTR

In tcplfit2: Concentration-Response Modeling of HTS or Transcriptomics Data

Sample concentration-response data set from HTTR

Description

A data set containing 6 of the active transcriptional signatures after perturbation of MCF7 cells with Clomiphene citrate (1:1).

Usage

signatures

Format

An object of class data.frame with 6 rows and 8 columns.

Details

A data frame with 6 rows and 8 variables:

• sample_id - experimental sample ID

• dtxsid - DSSTox generic substance ID

• name - chemical name

• signature - transcriptional signature name

• cutoff - the 95% confidence interval from the baseline response (2 lowest concentrations)

• onesd - one standard deviation of the baseline response

• conc - experimental concentrations, micromolar (uM)

• resp - transcriptional signature response for each experimental concentrations, ssGSEA score

Source

\Sexpr[results=rd]{tools:::Rd_expr_doi("https://doi.org/10.1093/toxsci/kfab009")}

References

Joshua A. Harrill, Logan J. Everett, Derik E. Haggard, Thomas Sheffield, Joseph L. Bundy, Clinton M. Willis, Russell S. Thomas, Imran Shah, Richard S. Judson, High-Throughput Transcriptomics Platform for Screening Environmental Chemicals, Toxicological Sciences, Volume 181, Issue 1, May 2021, Pages 68 - 89, https://doi.org/10.1093/toxsci/kfab009.

tcplfit2 documentation built on Oct. 11, 2023, 1:07 a.m.