call_combn_hits: Call significant responses for scored paired data.

In HenryWard/orthrus: Scoring Combinatorial CRISPR Screens

Call significant responses for scored paired data.

Description

Run this to call significant responses for data returned from score_combn_vs_single. Do NOT run this on data returned from score_conditions_vs_control.

Usage

call_combn_hits(
  scores,
  screen_names,
  fdr_threshold = 0.1,
  differential_threshold = 0.5,
  neg_type = "Negative",
  pos_type = "Positive"
)

Arguments

scores	Dataframe returned from score_combn_vs_single.
screen_names	A list of screen names scored in score_combn_vs_single for which to call significant effects.
fdr_threshold	Threshold below which to call gene effects as significant (default 0.1).
differential_threshold	Absolute value threshold on differential effects, below which gene effects are not called as significant (default 0.5).
neg_type	Label for significant effects with a negative differential effect (default "Negative").
pos_type	Label for significant effects with a positive differential effect (default "Positive").

Value

Dataframe of scored data with differential effects called as significant for the specified conditions.

HenryWard/orthrus documentation built on June 2, 2023, 10:28 p.m.