call_condition_hits: Call significant responses for scored data.

In HenryWard/orthrus: Scoring Combinatorial CRISPR Screens

Call significant responses for scored data.

Description

Run this to call significant responses for data returned from score_conditions_vs_control. Do NOT run this on data returned from score_combn_vs_single.

Usage

call_condition_hits(
  scores,
  control_screen_name,
  condition_screen_names,
  fdr_threshold = 0.1,
  differential_threshold = 0.5,
  neg_type = "Negative",
  pos_type = "Positive"
)

Arguments

scores	Dataframe returned from score_conditions_vs_control.
control_screen_name	Name of a control screen to test condition screens against.
condition_screen_names	A list of condition screen names to score against the control screen.
fdr_threshold	Threshold below which to call gene effects as significant (default 0.1).
differential_threshold	Absolute value threshold on differential effects, below which gene effects are not called as significant (default 0.5).
neg_type	Label for significant effects with a negative differential effect (default "Negative").
pos_type	Label for significant effects with a positive differential effect (default "Positive").

Value

Dataframe of scored data with differential effects called as significant for the specified conditions.

HenryWard/orthrus documentation built on June 2, 2023, 10:28 p.m.