In IDDI-BE/PhIdesign: Decision rules and simulation of model-assisted Phase I designs
# Target toxicity rate 10%
target_10_6lev <- list(c(0.04 ,0.05 ,0.06 ,0.07 ,0.08 ,0.09), # From Ji & Wang. J Clin Oncol 31:1785-1791
c(0.15 ,0.2 ,0.25 ,0.3 ,0.35 ,0.4 ),
c(0.01 ,0.1 ,0.2 ,0.25 ,0.3 ,0.35),
c(0.01 ,0.02 ,0.03 ,0.04 ,0.1 ,0.25),
c(0.05 ,0.4 ,0.5 ,0.6 ,0.65 ,0.7 ),
c(0.01 ,0.03 ,0.05 ,0.4 ,0.5 ,0.6 ),
c(0.01 ,0.02 ,0.03 ,0.04 ,0.05 ,0.4 ),
c(0.09 ,0.11 ,0.13 ,0.15 ,0.17 ,0.19),
c(0.05 ,0.07 ,0.09 ,0.11 ,0.13 ,0.15),
c(0.01 ,0.03 ,0.05 ,0.07 ,0.09 ,0.11),
c(0.02 ,0.04 ,0.08 ,0.12 ,0.17 ,0.25),
c(0.02 ,0.04 ,0.07 ,0.1 ,0.15 ,0.2 ),
c(0.1 ,0.15 ,0.2 ,0.25 ,0.3 ,0.35),
c(0.01 ,0.03 ,0.05 ,0.06 ,0.08 ,0.1 ))
# Target toxicity rate 15%
target_15_5lev <- list(c(0.15 ,0.20 ,0.25 ,0.30 ,0.40), # From Yuan et al. Clin Cancer Res;22:4291-301
c(0.15 ,0.23 ,0.30 ,0.40 ,0.50),
c(0.10 ,0.15 ,0.20 ,0.30 ,0.40),
c(0.10 ,0.15 ,0.25 ,0.35 ,0.50),
c(0.05 ,0.15 ,0.20 ,0.30 ,0.40),
c(0.05 ,0.15 ,0.25 ,0.35 ,0.50),
c(0.04 ,0.10 ,0.15 ,0.20 ,0.30),
c(0.04 ,0.10 ,0.15 ,0.25 ,0.40),
c(0.02 ,0.05 ,0.15 ,0.20 ,0.30),
c(0.02 ,0.05 ,0.15 ,0.25 ,0.40),
c(0.01 ,0.05 ,0.10 ,0.15 ,0.20),
c(0.01 ,0.05 ,0.10 ,0.15 ,0.25),
c(0.01 ,0.03 ,0.05 ,0.15 ,0.20),
c(0.01 ,0.03 ,0.05 ,0.15 ,0.25),
c(0.02 ,0.04 ,0.06 ,0.10 ,0.15),
c(0.01 ,0.02 ,0.04 ,0.05 ,0.15))
# Target toxicity rate 20%
target_20_5lev <- list(c(0.20 ,0.25 ,0.35 ,0.45 ,0.50), # From Yuan et al. Clin Cancer Res;22:4291-301
c(0.20 ,0.30 ,0.40 ,0.50 ,0.60),
c(0.15 ,0.20 ,0.25 ,0.35 ,0.45),
c(0.15 ,0.20 ,0.30 ,0.45 ,0.55),
c(0.10 ,0.20 ,0.25 ,0.35 ,0.45),
c(0.10 ,0.20 ,0.30 ,0.40 ,0.55),
c(0.08 ,0.15 ,0.20 ,0.25 ,0.35),
c(0.08 ,0.15 ,0.20 ,0.30 ,0.45),
c(0.05 ,0.10 ,0.20 ,0.25 ,0.40),
c(0.05 ,0.10 ,0.20 ,0.30 ,0.45),
c(0.05 ,0.10 ,0.15 ,0.20 ,0.25),
c(0.05 ,0.10 ,0.15 ,0.20 ,0.30),
c(0.02 ,0.06 ,0.10 ,0.20 ,0.25),
c(0.02 ,0.06 ,0.10 ,0.20 ,0.30),
c(0.02 ,0.05 ,0.07 ,0.10 ,0.20),
c(0.01 ,0.06 ,0.10 ,0.15 ,0.20))
target_20_6lev <- list(c(0.30 ,0.40 ,0.50 ,0.60 ,0.70 ,0.80),
c(0.20 ,0.30 ,0.40 ,0.50 ,0.60 ,0.70),
c(0.20 ,0.25 ,0.30 ,0.50 ,0.65 ,0.80),
c(0.10 ,0.20 ,0.30 ,0.40 ,0.50 ,0.60),
c(0.10 ,0.20 ,0.40 ,0.55 ,0.70 ,0.80),
c(0.10 ,0.15 ,0.20 ,0.30 ,0.50 ,0.65),
c(0.05 ,0.10 ,0.20 ,0.30 ,0.40 ,0.50),
c(0.025,0.05 ,0.15 ,0.20 ,0.40 ,0.65),
c(0.013,0.025,0.05 ,0.10 ,0.15 ,0.20),
c(0.025,0.05 ,0.10 ,0.20 ,0.40 ,0.55),
c(0.013,0.025,0.05 ,0.10 ,0.20 ,0.30))
target_20_6lev <- list(c(0.02 ,0.05 ,0.08 ,0.11 ,0.14 ,0.17), # From Ji & Wang. J Clin Oncol 31:1785-1791
c(0.25 ,0.35 ,0.4 ,0.5 ,0.6 ,0.7 ),
c(0.01 ,0.2 ,0.4 ,0.6 ,0.8 ,0.95),
c(0.04 ,0.06 ,0.08 ,0.1 ,0.2 ,0.5 ),
c(0.05 ,0.5 ,0.8 ,0.9 ,0.95 ,0.99),
c(0.01 ,0.05 ,0.1 ,0.5 ,0.7 ,0.9 ),
c(0.01 ,0.03 ,0.07 ,0.1 ,0.15 ,0.7 ),
c(0.19 ,0.21 ,0.23 ,0.25 ,0.27 ,0.29),
c(0.15 ,0.17 ,0.19 ,0.21 ,0.23 ,0.25),
c(0.11 ,0.13 ,0.15 ,0.17 ,0.19 ,0.21),
c(0.05 ,0.11 ,0.17 ,0.23 ,0.29 ,0.35),
c(0.05 ,0.1 ,0.15 ,0.2 ,0.3 ,0.4 ),
c(0.2 ,0.25 ,0.3 ,0.35 ,0.4 ,0.45),
c(0.05 ,0.08 ,0.11 ,0.14 ,0.17 ,0.2 ))
# Target toxicity rate 25%
target_25_5lev <- list(c(0.25 ,0.35 ,0.45 ,0.60 ,0.70),
c(0.25 ,0.32 ,0.40 ,0.50 ,0.60),
c(0.20 ,0.25 ,0.35 ,0.45 ,0.60),
c(0.18 ,0.25 ,0.32 ,0.40 ,0.50),
c(0.15 ,0.25 ,0.35 ,0.50 ,0.65),
c(0.13 ,0.25 ,0.32 ,0.40 ,0.50),
c(0.10 ,0.15 ,0.25 ,0.30 ,0.40),
c(0.10 ,0.18 ,0.25 ,0.32 ,0.40),
c(0.10 ,0.15 ,0.25 ,0.35 ,0.50),
c(0.06 ,0.13 ,0.25 ,0.32 ,0.40),
c(0.02 ,0.10 ,0.20 ,0.25 ,0.30),
c(0.02 ,0.10 ,0.18 ,0.25 ,0.32),
c(0.02 ,0.10 ,0.20 ,0.25 ,0.35),
c(0.01 ,0.07 ,0.13 ,0.25 ,0.32),
c(0.01 ,0.05 ,0.10 ,0.15 ,0.25),
c(0.01 ,0.06 ,0.12 ,0.18 ,0.25))
target_25_6lev <- list(c(0.35 ,0.45 ,0.55 ,0.65 ,0.75 ,0.85),
c(0.25 ,0.35 ,0.45 ,0.55 ,0.65 ,0.75),
c(0.25 ,0.30 ,0.35 ,0.55 ,0.70 ,0.85),
c(0.15 ,0.25 ,0.35 ,0.45 ,0.55 ,0.65),
c(0.15 ,0.25 ,0.45 ,0.60 ,0.75 ,0.85),
c(0.15 ,0.20 ,0.25 ,0.35 ,0.55 ,0.70),
c(0.05 ,0.15 ,0.25 ,0.35 ,0.45 ,0.55),
c(0.05 ,0.10 ,0.20 ,0.25 ,0.45 ,0.70),
c(0.025,0.05 ,0.10 ,0.15 ,0.20 ,0.25),
c(0.025,0.05 ,0.15 ,0.25 ,0.45 ,0.60),
c(0.025,0.05 ,0.10 ,0.15 ,0.25 ,0.35))
# Target toxicity rate 30%
target_30_3lev <- list(c(0.30 ,0.45 ,0.60),
c(0.20 ,0.30 ,0.45),
c(0.15, 0.30 ,0.45),
c(0.10 ,0.20 ,0.30),
c(0.05 ,0.20 ,0.30),
c(0.05 ,0.10 ,0.30),
c(0.02 ,0.05 ,0.30))
target_30_4lev <- list(c(0.30 ,0.40 ,0.50 ,0.60), # Adapted from target_30_5lev
c(0.30 ,0.45 ,0.60 ,0.70),
c(0.20 ,0.30 ,0.40 ,0.50),
c(0.20 ,0.30 ,0.45 ,0.60),
c(0.15, 0.30 ,0.40 ,0.50),
c(0.15, 0.30 ,0.45 ,0.60),
c(0.12 ,0.20 ,0.30 ,0.40),
c(0.12 ,0.20 ,0.30 ,0.45),
c(0.05 ,0.15 ,0.30 ,0.40),
c(0.05 ,0.15 ,0.30 ,0.45),
c(0.05, 0.12 ,0.20 ,0.30),
c(0.05, 0.12 ,0.20 ,0.30),
c(0.02 ,0.08 ,0.15 ,0.30),
c(0.02 ,0.08 ,0.15 ,0.30))
target_30_5lev <- list(c(0.30 ,0.40 ,0.50 ,0.60 ,0.70 ), # From Yuan et al. Clin Cancer Res;22:4291-301
c(0.30 ,0.45 ,0.60 ,0.70 ,0.80 ),
c(0.20 ,0.30 ,0.40 ,0.50 ,0.60 ),
c(0.20 ,0.30 ,0.45 ,0.60 ,0.70 ),
c(0.15, 0.30 ,0.40 ,0.50 ,0.60 ),
c(0.15, 0.30 ,0.45 ,0.60 ,0.70 ),
c(0.12 ,0.20 ,0.30 ,0.40 ,0.50 ),
c(0.12 ,0.20 ,0.30 ,0.45 ,0.60 ),
c(0.05 ,0.15 ,0.30 ,0.40 ,0.50 ),
c(0.05 ,0.15 ,0.30 ,0.45 ,0.60 ),
c(0.05, 0.12 ,0.20 ,0.30 ,0.40 ),
c(0.05, 0.12 ,0.20 ,0.30 ,0.45 ),
c(0.02 ,0.08 ,0.15 ,0.30 ,0.40 ),
c(0.02 ,0.08 ,0.15 ,0.30 ,0.45 ),
c(0.02, 0.10 ,0.15 ,0.20 ,0.30 ),
c(0.01, 0.04 ,0.08 ,0.15 ,0.30 ))
target_30_6lev <- list(c(0.40 ,0.50 ,0.60 ,0.70 ,0.80 ,0.90),
c(0.30 ,0.40 ,0.50 ,0.60 ,0.70 ,0.80),
c(0.30 ,0.35 ,0.40 ,0.60 ,0.75 ,0.90),
c(0.20 ,0.30 ,0.40 ,0.50 ,0.60 ,0.70),
c(0.20 ,0.30 ,0.50 ,0.65 ,0.80 ,0.90),
c(0.20 ,0.25 ,0.30 ,0.40 ,0.60 ,0.75),
c(0.10 ,0.20 ,0.30 ,0.40 ,0.50 ,0.60),
c(0.10 ,0.15 ,0.25 ,0.30 ,0.50 ,0.75),
c(0.05 ,0.10 ,0.15 ,0.20 ,0.25 ,0.30),
c(0.05 ,0.10 ,0.20 ,0.30 ,0.50 ,0.65),
c(0.025,0.05 ,0.10 ,0.20 ,0.30 ,0.40))
target_30_6lev <- list(c(0.02 ,0.05 ,0.1 ,0.15 ,0.2 ,0.25), # From Ji & Wang. J Clin Oncol 31:1785-1791.
c(0.35 ,0.45 ,0.5 ,0.6 ,0.7 ,0.8 ),
c(0.01 ,0.3 ,0.55 ,0.65 ,0.8 ,0.95),
c(0.04 ,0.06 ,0.08 ,0.1 ,0.3 ,0.6 ),
c(0.05 ,0.6 ,0.8 ,0.9 ,0.95 ,0.99),
c(0.01 ,0.05 ,0.1 ,0.6 ,0.7 ,0.9 ),
c(0.01 ,0.03 ,0.07 ,0.1 ,0.15 ,0.75),
c(0.29 ,0.31 ,0.33 ,0.35 ,0.37 ,0.39),
c(0.25 ,0.27 ,0.29 ,0.31 ,0.33 ,0.35),
c(0.21 ,0.23 ,0.25 ,0.27 ,0.29 ,0.31),
c(0.05 ,0.2 ,0.27 ,0.33 ,0.39 ,0.45),
c(0.05 ,0.1 ,0.2 ,0.3 ,0.4 ,0.4 ),
c(0.3 ,0.35 ,0.4 ,0.45 ,0.5 ,0.55),
c(0.15 ,0.18 ,0.21 ,0.24 ,0.27 ,0.3 ))
target_30_10lev <- list(c(0.40 ,0.45 ,0.50 ,0.55 ,0.60 ,0.65 ,0.70 ,0.75 ,0.80 ,0.85),
c(0.30 ,0.35 ,0.45 ,0.50 ,0.55 ,0.60 ,0.65 ,0.70 ,0.75 ,0.80),
c(0.20 ,0.25 ,0.30 ,0.35 ,0.45 ,0.50 ,0.55 ,0.60 ,0.65 ,0.70),
c(0.10 ,0.15 ,0.20 ,0.25 ,0.30 ,0.35 ,0.45 ,0.50 ,0.55 ,0.60),
c(0.075,0.10 ,0.125,0.15 ,0.20 ,0.25 ,0.30 ,0.35 ,0.45 ,0.50),
c(0.075,0.10 ,0.125,0.15 ,0.20 ,0.225,0.25 ,0.275,0.30 ,0.35))
IDDI-BE/PhIdesign documentation built on Feb. 7, 2024, 9:32 p.m.
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# Target toxicity rate 10% target_10_6lev <- list(c(0.04 ,0.05 ,0.06 ,0.07 ,0.08 ,0.09), # From Ji & Wang. J Clin Oncol 31:1785-1791 c(0.15 ,0.2 ,0.25 ,0.3 ,0.35 ,0.4 ), c(0.01 ,0.1 ,0.2 ,0.25 ,0.3 ,0.35), c(0.01 ,0.02 ,0.03 ,0.04 ,0.1 ,0.25), c(0.05 ,0.4 ,0.5 ,0.6 ,0.65 ,0.7 ), c(0.01 ,0.03 ,0.05 ,0.4 ,0.5 ,0.6 ), c(0.01 ,0.02 ,0.03 ,0.04 ,0.05 ,0.4 ), c(0.09 ,0.11 ,0.13 ,0.15 ,0.17 ,0.19), c(0.05 ,0.07 ,0.09 ,0.11 ,0.13 ,0.15), c(0.01 ,0.03 ,0.05 ,0.07 ,0.09 ,0.11), c(0.02 ,0.04 ,0.08 ,0.12 ,0.17 ,0.25), c(0.02 ,0.04 ,0.07 ,0.1 ,0.15 ,0.2 ), c(0.1 ,0.15 ,0.2 ,0.25 ,0.3 ,0.35), c(0.01 ,0.03 ,0.05 ,0.06 ,0.08 ,0.1 )) # Target toxicity rate 15% target_15_5lev <- list(c(0.15 ,0.20 ,0.25 ,0.30 ,0.40), # From Yuan et al. Clin Cancer Res;22:4291-301 c(0.15 ,0.23 ,0.30 ,0.40 ,0.50), c(0.10 ,0.15 ,0.20 ,0.30 ,0.40), c(0.10 ,0.15 ,0.25 ,0.35 ,0.50), c(0.05 ,0.15 ,0.20 ,0.30 ,0.40), c(0.05 ,0.15 ,0.25 ,0.35 ,0.50), c(0.04 ,0.10 ,0.15 ,0.20 ,0.30), c(0.04 ,0.10 ,0.15 ,0.25 ,0.40), c(0.02 ,0.05 ,0.15 ,0.20 ,0.30), c(0.02 ,0.05 ,0.15 ,0.25 ,0.40), c(0.01 ,0.05 ,0.10 ,0.15 ,0.20), c(0.01 ,0.05 ,0.10 ,0.15 ,0.25), c(0.01 ,0.03 ,0.05 ,0.15 ,0.20), c(0.01 ,0.03 ,0.05 ,0.15 ,0.25), c(0.02 ,0.04 ,0.06 ,0.10 ,0.15), c(0.01 ,0.02 ,0.04 ,0.05 ,0.15)) # Target toxicity rate 20% target_20_5lev <- list(c(0.20 ,0.25 ,0.35 ,0.45 ,0.50), # From Yuan et al. Clin Cancer Res;22:4291-301 c(0.20 ,0.30 ,0.40 ,0.50 ,0.60), c(0.15 ,0.20 ,0.25 ,0.35 ,0.45), c(0.15 ,0.20 ,0.30 ,0.45 ,0.55), c(0.10 ,0.20 ,0.25 ,0.35 ,0.45), c(0.10 ,0.20 ,0.30 ,0.40 ,0.55), c(0.08 ,0.15 ,0.20 ,0.25 ,0.35), c(0.08 ,0.15 ,0.20 ,0.30 ,0.45), c(0.05 ,0.10 ,0.20 ,0.25 ,0.40), c(0.05 ,0.10 ,0.20 ,0.30 ,0.45), c(0.05 ,0.10 ,0.15 ,0.20 ,0.25), c(0.05 ,0.10 ,0.15 ,0.20 ,0.30), c(0.02 ,0.06 ,0.10 ,0.20 ,0.25), c(0.02 ,0.06 ,0.10 ,0.20 ,0.30), c(0.02 ,0.05 ,0.07 ,0.10 ,0.20), c(0.01 ,0.06 ,0.10 ,0.15 ,0.20)) target_20_6lev <- list(c(0.30 ,0.40 ,0.50 ,0.60 ,0.70 ,0.80), c(0.20 ,0.30 ,0.40 ,0.50 ,0.60 ,0.70), c(0.20 ,0.25 ,0.30 ,0.50 ,0.65 ,0.80), c(0.10 ,0.20 ,0.30 ,0.40 ,0.50 ,0.60), c(0.10 ,0.20 ,0.40 ,0.55 ,0.70 ,0.80), c(0.10 ,0.15 ,0.20 ,0.30 ,0.50 ,0.65), c(0.05 ,0.10 ,0.20 ,0.30 ,0.40 ,0.50), c(0.025,0.05 ,0.15 ,0.20 ,0.40 ,0.65), c(0.013,0.025,0.05 ,0.10 ,0.15 ,0.20), c(0.025,0.05 ,0.10 ,0.20 ,0.40 ,0.55), c(0.013,0.025,0.05 ,0.10 ,0.20 ,0.30)) target_20_6lev <- list(c(0.02 ,0.05 ,0.08 ,0.11 ,0.14 ,0.17), # From Ji & Wang. J Clin Oncol 31:1785-1791 c(0.25 ,0.35 ,0.4 ,0.5 ,0.6 ,0.7 ), c(0.01 ,0.2 ,0.4 ,0.6 ,0.8 ,0.95), c(0.04 ,0.06 ,0.08 ,0.1 ,0.2 ,0.5 ), c(0.05 ,0.5 ,0.8 ,0.9 ,0.95 ,0.99), c(0.01 ,0.05 ,0.1 ,0.5 ,0.7 ,0.9 ), c(0.01 ,0.03 ,0.07 ,0.1 ,0.15 ,0.7 ), c(0.19 ,0.21 ,0.23 ,0.25 ,0.27 ,0.29), c(0.15 ,0.17 ,0.19 ,0.21 ,0.23 ,0.25), c(0.11 ,0.13 ,0.15 ,0.17 ,0.19 ,0.21), c(0.05 ,0.11 ,0.17 ,0.23 ,0.29 ,0.35), c(0.05 ,0.1 ,0.15 ,0.2 ,0.3 ,0.4 ), c(0.2 ,0.25 ,0.3 ,0.35 ,0.4 ,0.45), c(0.05 ,0.08 ,0.11 ,0.14 ,0.17 ,0.2 )) # Target toxicity rate 25% target_25_5lev <- list(c(0.25 ,0.35 ,0.45 ,0.60 ,0.70), c(0.25 ,0.32 ,0.40 ,0.50 ,0.60), c(0.20 ,0.25 ,0.35 ,0.45 ,0.60), c(0.18 ,0.25 ,0.32 ,0.40 ,0.50), c(0.15 ,0.25 ,0.35 ,0.50 ,0.65), c(0.13 ,0.25 ,0.32 ,0.40 ,0.50), c(0.10 ,0.15 ,0.25 ,0.30 ,0.40), c(0.10 ,0.18 ,0.25 ,0.32 ,0.40), c(0.10 ,0.15 ,0.25 ,0.35 ,0.50), c(0.06 ,0.13 ,0.25 ,0.32 ,0.40), c(0.02 ,0.10 ,0.20 ,0.25 ,0.30), c(0.02 ,0.10 ,0.18 ,0.25 ,0.32), c(0.02 ,0.10 ,0.20 ,0.25 ,0.35), c(0.01 ,0.07 ,0.13 ,0.25 ,0.32), c(0.01 ,0.05 ,0.10 ,0.15 ,0.25), c(0.01 ,0.06 ,0.12 ,0.18 ,0.25)) target_25_6lev <- list(c(0.35 ,0.45 ,0.55 ,0.65 ,0.75 ,0.85), c(0.25 ,0.35 ,0.45 ,0.55 ,0.65 ,0.75), c(0.25 ,0.30 ,0.35 ,0.55 ,0.70 ,0.85), c(0.15 ,0.25 ,0.35 ,0.45 ,0.55 ,0.65), c(0.15 ,0.25 ,0.45 ,0.60 ,0.75 ,0.85), c(0.15 ,0.20 ,0.25 ,0.35 ,0.55 ,0.70), c(0.05 ,0.15 ,0.25 ,0.35 ,0.45 ,0.55), c(0.05 ,0.10 ,0.20 ,0.25 ,0.45 ,0.70), c(0.025,0.05 ,0.10 ,0.15 ,0.20 ,0.25), c(0.025,0.05 ,0.15 ,0.25 ,0.45 ,0.60), c(0.025,0.05 ,0.10 ,0.15 ,0.25 ,0.35)) # Target toxicity rate 30% target_30_3lev <- list(c(0.30 ,0.45 ,0.60), c(0.20 ,0.30 ,0.45), c(0.15, 0.30 ,0.45), c(0.10 ,0.20 ,0.30), c(0.05 ,0.20 ,0.30), c(0.05 ,0.10 ,0.30), c(0.02 ,0.05 ,0.30)) target_30_4lev <- list(c(0.30 ,0.40 ,0.50 ,0.60), # Adapted from target_30_5lev c(0.30 ,0.45 ,0.60 ,0.70), c(0.20 ,0.30 ,0.40 ,0.50), c(0.20 ,0.30 ,0.45 ,0.60), c(0.15, 0.30 ,0.40 ,0.50), c(0.15, 0.30 ,0.45 ,0.60), c(0.12 ,0.20 ,0.30 ,0.40), c(0.12 ,0.20 ,0.30 ,0.45), c(0.05 ,0.15 ,0.30 ,0.40), c(0.05 ,0.15 ,0.30 ,0.45), c(0.05, 0.12 ,0.20 ,0.30), c(0.05, 0.12 ,0.20 ,0.30), c(0.02 ,0.08 ,0.15 ,0.30), c(0.02 ,0.08 ,0.15 ,0.30)) target_30_5lev <- list(c(0.30 ,0.40 ,0.50 ,0.60 ,0.70 ), # From Yuan et al. Clin Cancer Res;22:4291-301 c(0.30 ,0.45 ,0.60 ,0.70 ,0.80 ), c(0.20 ,0.30 ,0.40 ,0.50 ,0.60 ), c(0.20 ,0.30 ,0.45 ,0.60 ,0.70 ), c(0.15, 0.30 ,0.40 ,0.50 ,0.60 ), c(0.15, 0.30 ,0.45 ,0.60 ,0.70 ), c(0.12 ,0.20 ,0.30 ,0.40 ,0.50 ), c(0.12 ,0.20 ,0.30 ,0.45 ,0.60 ), c(0.05 ,0.15 ,0.30 ,0.40 ,0.50 ), c(0.05 ,0.15 ,0.30 ,0.45 ,0.60 ), c(0.05, 0.12 ,0.20 ,0.30 ,0.40 ), c(0.05, 0.12 ,0.20 ,0.30 ,0.45 ), c(0.02 ,0.08 ,0.15 ,0.30 ,0.40 ), c(0.02 ,0.08 ,0.15 ,0.30 ,0.45 ), c(0.02, 0.10 ,0.15 ,0.20 ,0.30 ), c(0.01, 0.04 ,0.08 ,0.15 ,0.30 )) target_30_6lev <- list(c(0.40 ,0.50 ,0.60 ,0.70 ,0.80 ,0.90), c(0.30 ,0.40 ,0.50 ,0.60 ,0.70 ,0.80), c(0.30 ,0.35 ,0.40 ,0.60 ,0.75 ,0.90), c(0.20 ,0.30 ,0.40 ,0.50 ,0.60 ,0.70), c(0.20 ,0.30 ,0.50 ,0.65 ,0.80 ,0.90), c(0.20 ,0.25 ,0.30 ,0.40 ,0.60 ,0.75), c(0.10 ,0.20 ,0.30 ,0.40 ,0.50 ,0.60), c(0.10 ,0.15 ,0.25 ,0.30 ,0.50 ,0.75), c(0.05 ,0.10 ,0.15 ,0.20 ,0.25 ,0.30), c(0.05 ,0.10 ,0.20 ,0.30 ,0.50 ,0.65), c(0.025,0.05 ,0.10 ,0.20 ,0.30 ,0.40)) target_30_6lev <- list(c(0.02 ,0.05 ,0.1 ,0.15 ,0.2 ,0.25), # From Ji & Wang. J Clin Oncol 31:1785-1791. c(0.35 ,0.45 ,0.5 ,0.6 ,0.7 ,0.8 ), c(0.01 ,0.3 ,0.55 ,0.65 ,0.8 ,0.95), c(0.04 ,0.06 ,0.08 ,0.1 ,0.3 ,0.6 ), c(0.05 ,0.6 ,0.8 ,0.9 ,0.95 ,0.99), c(0.01 ,0.05 ,0.1 ,0.6 ,0.7 ,0.9 ), c(0.01 ,0.03 ,0.07 ,0.1 ,0.15 ,0.75), c(0.29 ,0.31 ,0.33 ,0.35 ,0.37 ,0.39), c(0.25 ,0.27 ,0.29 ,0.31 ,0.33 ,0.35), c(0.21 ,0.23 ,0.25 ,0.27 ,0.29 ,0.31), c(0.05 ,0.2 ,0.27 ,0.33 ,0.39 ,0.45), c(0.05 ,0.1 ,0.2 ,0.3 ,0.4 ,0.4 ), c(0.3 ,0.35 ,0.4 ,0.45 ,0.5 ,0.55), c(0.15 ,0.18 ,0.21 ,0.24 ,0.27 ,0.3 )) target_30_10lev <- list(c(0.40 ,0.45 ,0.50 ,0.55 ,0.60 ,0.65 ,0.70 ,0.75 ,0.80 ,0.85), c(0.30 ,0.35 ,0.45 ,0.50 ,0.55 ,0.60 ,0.65 ,0.70 ,0.75 ,0.80), c(0.20 ,0.25 ,0.30 ,0.35 ,0.45 ,0.50 ,0.55 ,0.60 ,0.65 ,0.70), c(0.10 ,0.15 ,0.20 ,0.25 ,0.30 ,0.35 ,0.45 ,0.50 ,0.55 ,0.60), c(0.075,0.10 ,0.125,0.15 ,0.20 ,0.25 ,0.30 ,0.35 ,0.45 ,0.50), c(0.075,0.10 ,0.125,0.15 ,0.20 ,0.225,0.25 ,0.275,0.30 ,0.35))
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