combineStrandBiasResults: combine Transcription and Replication strand bias results

In Nik-Zainal-Group/signature.tools.lib: signature.tools.lib

combine Transcription and Replication strand bias results

Description

This function combines the transcription/replication strand bias results obtained using the sampleStrandBias function. For example, sampleStrandBias can be run multiple times and each result object added to a named list, and then the list used as input for the combineStrandBiasResults function. Results from multiple samples will then be combined to obtain statistics such as average, standard deviation and p-value to determine whether the bias is significant.

Usage

combineStrandBiasResults(biasResObjList)

Arguments

biasResObjList

R list object containing a list of strand bias result objects, each obtained using the using the sampleStrandBias function. This should be a named list, for example each element name could be a sample name.

Examples

biasResObjList <- list()
biasResObjList[["sample1"]] <- sampleStrandBias(sample1_snvs)
biasResObjList[["sample2"]] <- sampleStrandBias(sample2_snvs)
biasResObjList[["sample3"]] <- sampleStrandBias(sample3_snvs)
res <- combineStrandBiasResults(biasResObjList)

Nik-Zainal-Group/signature.tools.lib documentation built on April 13, 2025, 5:50 p.m.