convertExposuresFromOrganToRefSigs: convertExposuresFromOrganToRefSigs

In Nik-Zainal-Group/signature.tools.lib: signature.tools.lib

convertExposuresFromOrganToRefSigs

Description

This function converts the exposures matrix obtained from fitting organ-specific signatures into reference signatures exposures. The function will detect the version of the signatures automatically.

Usage

convertExposuresFromOrganToRefSigs(expMatrix, typemut = "subs")

Arguments

expMatrix	exposures matrix obtained from fitting organ-specific signatures, with samples as columns and organ-specific signature names as row names. Must contain only organ-specific signature exposures
typemut	either subs, DNV or rearr

Value

exposure matrix converted in reference signatures exposures, or NULL if expMatrix doesn't contain only organ-specific signatures or typemut is unknown

References

A. Degasperi, T. D. Amarante, J. Czarnecki, S. Shooter, X. Zou, D. Glodzik, S. Morganella, A. S. Nanda, C. Badja, G. Koh, S. E. Momen, I. Georgakopoulos-Soares, J. M. L. Dias, J. Young, Y. Memari, H. Davies, S. Nik-Zainal. A practical framework and online tool for mutational signature analyses show intertissue variation and driver dependencies, Nature Cancer, https://doi.org/10.1038/s43018-020-0027-5, 2020.

Nik-Zainal-Group/signature.tools.lib documentation built on April 13, 2025, 5:50 p.m.