compareSignatures: Compares identified denovo mutational signatures to known...

In PoisonAlien/maftools: Summarize, Analyze and Visualize MAF Files

Compares identified denovo mutational signatures to known COSMIC signatures

Description

Takes results from extractSignatures and compares them known COSMIC signatures. Two COSMIC databases are used for comparisons - "legacy" which includes 30 signaures, and "SBS" - which includes updated/refined 65 signatures

Usage

compareSignatures(nmfRes, sig_db = "SBS_v34", verbose = TRUE)

Arguments

nmfRes	results from extractSignatures
sig_db	can be legacy, SBS, SBS_v34. Default SBS_v34
verbose	Default TRUE

Details

SBS signature database was obtained from https://www.synapse.org/#!Synapse:syn11738319.7

Value

list containing cosine smilarities, aetiologies if available, and best match.

See Also

trinucleotideMatrix extractSignatures plotSignatures

PoisonAlien/maftools documentation built on April 7, 2024, 2:49 a.m.