DRAnalysis: Assess differences in tumor volume between arms

In SCBIT-YYLab/DRAP: Drug Response Analysis Tailored for Drug Testing on Patient-Derived Tumor Models

Description

Assess differences in tumor volume between arms.

Usage

DRAnalysis (data, pattern = c('oneAN','TAN'),
                   method=c('endpoint.ANOVA','endpoint.KW','endpoint.SRH',
                            'GR.ANOVA','GR.KW','GR.SRH','mixed.ANOVA','LMM'))

Arguments

data	a data frame of measured tumor volume data.
pattern	the pattern of PDX trial design, "oneAN" or "TAN".
method	the method used to analysis.

Details

DRAnalysis offers both parametic and non-parametic statistic methods to access whether the arms have significant effect on tumor volume. users nedd to choose the proper method based on the feature of data and the suitable conditions.

Value

The statistical analysis results of the choosen method.

Examples

###oneAN pattern
data(oneAN.volume.data)
DRAnalysis(oneAN.volume.data,pattern = 'oneAN',method = 'endpoint.ANOVA')
DRAnalysis(oneAN.volume.data,pattern = 'oneAN',method = 'endpoint.KW')
DRAnalysis(oneAN.volume.data,pattern = 'oneAN',method = 'GR.ANOVA')
DRAnalysis(oneAN.volume.data,pattern = 'oneAN',method = 'mixed.ANOVA')
DRAnalysis(oneAN.volume.data,pattern = 'oneAN',method = 'LMM')

###TAN pattern
data(TAN.volume.data)
DRAnalysis(TAN.volume.data,pattern = 'TAN',method = 'endpoint.ANOVA')
DRAnalysis(TAN.volume.data,pattern = 'TAN',method = 'endpoint.SRH')
DRAnalysis(TAN.volume.data,pattern = 'TAN',method = 'LMM')

SCBIT-YYLab/DRAP documentation built on April 7, 2020, 2:03 a.m.