pgo_binary: Probability to go to phase III for multiarm programs with...

In Sterniii3/drugdevelopR: Utility-Based Optimal Phase II/III Drug Development Planning

Probability to go to phase III for multiarm programs with binary distributed outcomes

Description

Given our parameters this function calculates the probability to go to phase III after the second phase was conducted. The considered strategies are as follows:

• 1. Strategy: Only best promising treatment goes to phase III

Usage

pgo_binary(RRgo, n2, p0, p11, p12, strategy, case)

Arguments

RRgo	threshold value for the go/no-go decision rule
n2	total sample size for phase II; must be even number
p0	assumed true rate of control group
p11	assumed true rate of treatment group
p12	assumed true rate of treatment group
strategy	choose Strategy: 1 ("only best promising"), 2 ("all promising")
case	different cases: 1 ("nogo"), 21 (treatment 1 is promising, treatment 2 is not), 22 (treatment 2 is promising, treatment 1 is not), 31 (both treatments are promising, treatment 1 is better), 32 (both treatments are promising, treatment 2 is better)

Value

The function pgo_binary() returns the probability to go to phase III.

Examples

res <- pgo_binary(RRgo = 0.8 ,n2 = 50 ,p0 = 0.6, p11 =  0.3, p12 = 0.5,strategy = 2, case = 31)

Sterniii3/drugdevelopR documentation built on Jan. 26, 2024, 6:17 a.m.