pw: Probabilty that effect in endpoint one is larger than in...

In Sterniii3/drugdevelopR: Utility-Based Optimal Phase II/III Drug Development Planning

Probabilty that effect in endpoint one is larger than in endpoint two

Description

This function calculated the probability that the treatment effect in endpoint one (or endpoint x) is larger than in endpoint two (or endpoint y), i.e. P(x>y) = P(x-y>0)

Usage

pw(n2, hr1, hr2, id1, id2, fixed, rho)

Arguments

n2	total sample size for phase II; must be even number
hr1	assumed true treatment effect on HR scale for endpoint OS
hr2	assumed true treatment effect on HR scale for endpoint PFS
id1	amount of information for hr1 in terms of number of events
id2	amount of information for hr2 in terms of number of events
fixed	choose if true treatment effects are fixed or random
rho	correlation between the two endpoints

Details

Z=X-Y is normally distributed with expectation mu_x - mu_y and variance sigma_x + sigma_y- 2 rho sdx sdy

Value

The output of the function pw() is the probability that endpoint one has a better result than endpoint two

Sterniii3/drugdevelopR documentation built on Jan. 26, 2024, 6:17 a.m.