utility_bias_normal | R Documentation |
The utility function calculates the expected utility of our drug development program and is given as gains minus costs and depends on the parameters and the expected probability of a successful program.
The utility is in a further step maximized by the optimal_bias_normal()
function.
utility_normal_L(
n2,
kappa,
Adj,
w,
Delta1,
Delta2,
in1,
in2,
a,
b,
alpha,
beta,
c2,
c3,
c02,
c03,
K,
N,
S,
steps1,
stepm1,
stepl1,
b1,
b2,
b3,
fixed
)
utility_normal_L2(
n2,
kappa,
Adj,
w,
Delta1,
Delta2,
in1,
in2,
a,
b,
alpha,
beta,
c2,
c3,
c02,
c03,
K,
N,
S,
steps1,
stepm1,
stepl1,
b1,
b2,
b3,
fixed
)
utility_normal_R(
n2,
kappa,
Adj,
w,
Delta1,
Delta2,
in1,
in2,
a,
b,
alpha,
beta,
c2,
c3,
c02,
c03,
K,
N,
S,
steps1,
stepm1,
stepl1,
b1,
b2,
b3,
fixed
)
utility_normal_R2(
n2,
kappa,
Adj,
w,
Delta1,
Delta2,
in1,
in2,
a,
b,
alpha,
beta,
c2,
c3,
c02,
c03,
K,
N,
S,
steps1,
stepm1,
stepl1,
b1,
b2,
b3,
fixed
)
n2 |
total sample size for phase II; must be even number |
kappa |
threshold value for the go/no-go decision rule |
Adj |
adjustment parameter |
w |
weight for mixture prior distribution |
Delta1 |
assumed true treatment effect for standardized difference in means |
Delta2 |
assumed true treatment effect for standardized difference in means |
in1 |
amount of information for |
in2 |
amount of information for |
a |
lower boundary for the truncation |
b |
upper boundary for the truncation |
alpha |
significance level |
beta |
|
c2 |
variable per-patient cost for phase II |
c3 |
variable per-patient cost for phase III |
c02 |
fixed cost for phase II |
c03 |
fixed cost for phase III |
K |
constraint on the costs of the program, default: Inf, e.g. no constraint |
N |
constraint on the total expected sample size of the program, default: Inf, e.g. no constraint |
S |
constraint on the expected probability of a successful program, default: -Inf, e.g. no constraint |
steps1 |
lower boundary for effect size category |
stepm1 |
lower boundary for effect size category |
stepl1 |
lower boundary for effect size category |
b1 |
expected gain for effect size category |
b2 |
expected gain for effect size category |
b3 |
expected gain for effect size category |
fixed |
choose if true treatment effects are fixed or random, if TRUE Delta1 is used as fixed effect |
The output of the functions utility_normal_L()
, utility_normal_L2()
, utility_normal_R()
and utility_normal_R2()
is the expected utility of the program.
res <- utility_normal_L(kappa = 0.1, n2 = 50, Adj = 0,
alpha = 0.025, beta = 0.1, w = 0.3,
Delta1 = 0.375, Delta2 = 0.625,
in1 = 300, in2 = 600,
a = 0.25, b = 0.75,
c2 = 0.75, c3 = 1, c02 = 100, c03 = 150,
K = Inf, N = Inf, S = -Inf,
steps1 = 0, stepm1 = 0.5, stepl1 = 0.8,
b1 = 3000, b2 = 8000, b3 = 10000,
fixed = TRUE)
res <- utility_normal_L2(kappa = 0.1, n2 = 50, Adj = 0,
alpha = 0.025, beta = 0.1, w = 0.3,
Delta1 = 0.375, Delta2 = 0.625,
in1 = 300, in2 = 600,
a = 0.25, b = 0.75,
c2 = 0.75, c3 = 1, c02 = 100, c03 = 150,
K = Inf, N = Inf, S = -Inf,
steps1 = 0, stepm1 = 0.5, stepl1 = 0.8,
b1 = 3000, b2 = 8000, b3 = 10000,
fixed = TRUE)
res <- utility_normal_R(kappa = 0.1, n2 = 50, Adj = 1,
alpha = 0.025, beta = 0.1, w = 0.3,
Delta1 = 0.375, Delta2 = 0.625,
in1 = 300, in2 = 600,
a = 0.25, b = 0.75,
c2 = 0.75, c3 = 1, c02 = 100, c03 = 150,
K = Inf, N = Inf, S = -Inf,
steps1 = 0, stepm1 = 0.5, stepl1 = 0.8,
b1 = 3000, b2 = 8000, b3 = 10000,
fixed = TRUE)
res <- utility_normal_R2(kappa = 0.1, n2 = 50, Adj = 1,
alpha = 0.025, beta = 0.1, w = 0.3,
Delta1 = 0.375, Delta2 = 0.625,
in1 = 300, in2 = 600,
a = 0.25, b = 0.75,
c2 = 0.75, c3 = 1, c02 = 100, c03 = 150,
K = Inf, N = Inf, S = -Inf,
steps1 = 0, stepm1 = 0.5, stepl1 = 0.8,
b1 = 3000, b2 = 8000, b3 = 10000,
fixed = TRUE)
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