aop3e: Overall p-value (Method 3 of Nhacolo and Brannath, 2018).

In arsenionhacolo/InferenceBEAGSD: Inference for Binary Endpoint Adaptive Group-Sequential Designs

Description

aop3e calculates the overall p-value for adaptive two-stage designs with binary endpoint using the Method 3 (see Nhacolo and Brannath, 2018).

Usage

aop3e(dsgn, x1o, xo, newpi0 = NULL)

Arguments

dsgn	Dataframe containing one of the designs in EKOADwn.
x1o	The observed stage 1 number of responses.
xo	The total observed number of responses.
newpi0	New response probability that replaces the one under the null hypothesis. Omit it if the intention is only to calculate the overall p-value.

Details

This is one of the four methods proposed by Nhacolo and Brannath (2018) primarily for single-arm adaptive two-stage group sequential designs with a binary endpoint.

Value

p-value.

Author(s)

Arsenio Nhacolo

References

Nhacolo, A. and Brannath, W. Interval and point estimation in adaptive Phase II trials with binary endpoint. Stat Methods Med Res, 2018.

See Also

aop1, aop1e, aop2, aop2e, aop2v2, aop2ev2

arsenionhacolo/InferenceBEAGSD documentation built on May 9, 2019, 4:10 a.m.