pp: UMVCUE

In arsenionhacolo/InferenceBEAGSD: Inference for Binary Endpoint Adaptive Group-Sequential Designs

Description

Calculates the uniformly minimum variance conditionally unbiased estimator (UMVCUE) of the true response probability.

Usage

pp(s, n1, r1, n)

Arguments

s	Total number of successes.
n1	Stage 1 sample size.
r1	Stage 1 critical value (trial is stopped at stage 1 if the number of successes is at most r1).
n	Total sample size.

Details

The UMVCUE (Pepe et al., 2009) is conditional on on proceeding to the second stage. he sample proportion is used when the trial stopped at first stage.

Value

Estimate of the response rate.

Author(s)

Arsenio Nhacolo

References

Pepe, M. S.; Feng, Z.; Longton, G. and Koopmeiners, J. Conditional estimation of sensitivity and specificity from a phase 2 biomarker study allowing early termination for futility. Stat Med, 2009, 28, 762-779.

See Also

pm, pg, pu and pk.

Examples

pp(21, 19, 4, 54)

arsenionhacolo/InferenceBEAGSD documentation built on May 9, 2019, 4:10 a.m.