pg: Bias-reduced estimator

In arsenionhacolo/InferenceBEAGSD: Inference for Binary Endpoint Adaptive Group-Sequential Designs

Description

Calculates the bias-reduced estimator of the true response rate as proposed by Guo and Liu (2005).

Usage

pg(s, n1, r1, n)

Arguments

s	Total number of successes.
n1	Stage 1 sample size.
r1	Stage 1 critical value (trial is stopped at stage 1 if the number of successes is at most r1).
n	Total sample size.

Details

It uses bias subtraction, with bias calculated by sbias and response rate estimated by pm.

Value

Estimate of the response rate.

Author(s)

Arsenio Nhacolo

References

Guo, H. Y. and Liu, A. A simple and efficient bias-reduced estimator of response probability following a group sequential phase II trial. J Biopharm Stat, 2005, 15, 773-781.

See Also

sbias, pm, pu, pp and pk.

Examples

pg(21, 19, 4, 54)

arsenionhacolo/InferenceBEAGSD documentation built on May 9, 2019, 4:10 a.m.