pu: UMVUE

In arsenionhacolo/InferenceBEAGSD: Inference for Binary Endpoint Adaptive Group-Sequential Designs

Description

Calculates the uniformly minimum variance unbiased estimator (UMVUE) of the true response probability.

Usage

pu(s, n1, r1, n)

Arguments

s	Total number of successes.
n1	Stage 1 sample size.
r1	Stage 1 critical value (trial is stopped at stage 1 if the number of successes is at most r1).
n	Total sample size.

Details

The UMVUE is based on approach by Grishick et al. (1946). It was first considered by Chang et al. (1989) and further studied by Jung et al. (2004).

Value

Estimate of the response rate.

Author(s)

Arsenio Nhacolo

References

Jung, S.-H. and Kim, K. M. On the estimation of the binomial probability in multistage clinical trials. Stat Med, 2004, 23, 881-896.

See Also

pm, pg, pp and pk.

Examples

pu(21, 19, 4, 54)

arsenionhacolo/InferenceBEAGSD documentation built on May 9, 2019, 4:10 a.m.