simEQTL: Simulate eQTL reference panel

In bhattacharya-a-bt/MOSTWAS: Multi-Omic Strategies for Transcriptome-Wide Association Studies

Simulate eQTL reference panel

Description

The function creates a eQTL reference panel for MOSTWAS methods with genotypes, expression, mediator intensities, and QTLs.

Usage

simEQTL(
  geno.loc,
  geno.dis,
  nqtl,
  b_qtls.loc,
  b_qtls.dis,
  eqtl_h2.loc,
  eqtl_h2.dis,
  numMed
)

Arguments

geno.loc	data.frame, reference genotypes for local SNPs
geno.dis	data.frame, reference genotypes for distal SNPs
nqtl	integer, sample size
b_qtls.loc	vector, local eQTLs effect sizes
b_qtls.dis	vector, distal eQTLs effect sizes
eqtl_h2.loc	numeric, local heritability of expression
eqtl_h2.dis	numeric, distal heritability of expression
numMed	integer, number of mediators

Value

list of matrices of local and distal simulated genotypes, expression, mediator intensities, vector of final distal eQTL effect sizes

bhattacharya-a-bt/MOSTWAS documentation built on April 6, 2023, 12:20 a.m.