testTME: Run TME tests through a data.frame of mediators

In bhattacharya-a-bt/MOSTWAS: Multi-Omic Strategies for Transcriptome-Wide Association Studies

Run TME tests through a data.frame of mediators

Description

The function runs Sobel or permutation testing

Usage

testTME(
  i,
  mediator,
  qtMed,
  transSNPs,
  pheno,
  sobel = F,
  nperms = 1000,
  cores,
  covariates,
  parallel = "no"
)

Arguments

i	integer, row of data.frame
mediator	data.frame, mediator intensities
qtMed	data.frame, mediator QTL results
transSNPs	vector, character vector of distal-eSNPs
sobel	logical, T/F to use Sobel test
nperms	integer, number of permutations
cores	integer, number of parallel ocres
covariates	data.frame, covariates
parallel	character, boots input for parallelization

Value

list with TME and P-value

bhattacharya-a-bt/MOSTWAS documentation built on April 6, 2023, 12:20 a.m.