simGWAS: Simulate eQTL reference panel

In bhattacharya-a-bt/MOSTWAS: Multi-Omic Strategies for Transcriptome-Wide Association Studies

Simulate eQTL reference panel

Description

The function creates a eQTL reference panel for MOSTWAS methods with genotypes, expression, mediator intensities, and QTLs.

Usage

simGWAS(geno.loc, geno.dis, ngwas, b_qtls.loc, b_qtls.dis, var_explained)

Arguments

geno.loc	data.frame, reference genotypes for local SNPs
geno.dis	data.frame, reference genotypes for distal SNPs
ngwas	integer, sample size
b_qtls.loc	vector, local eQTLs effect sizes
b_qtls.dis	vector, distal eQTLs effect sizes
var_explained	numeric, total variance explained in phenotype

Value

list of GWAS summary statistics, total eQTL effect size, matrix of simulated genotypes, vector of trait

bhattacharya-a-bt/MOSTWAS documentation built on April 6, 2023, 12:20 a.m.