scones_: Find connected explanatory features
In hclimente/martini: GWAS Incorporating Networks

scones_

R Documentation

Find connected explanatory features

Description

Finds the features maximally associated with a phenotype while being connected in an underlying network.

Usage

scones_(X, y, featnames, net, eta, lambda)

Arguments

`X`	n x d design matrix
`y`	Vector of length n with the outcomes
`featnames`	Vector of length d with the feature names
`net`	An igraph network that connects the SNPs.
`eta`	Value of the eta parameter.
`lambda`	Value of the lambda parameter.

Value

A copy of the SnpMatrix$map data.frame, with the following additions:

c: contains the univariate association score for every single SNP.
selected: logical vector indicating if the SNP was selected by SConES or not.
module: integer with the number of the module the SNP belongs to.

Examples

X <- as(minigwas[['genotypes']], 'numeric')
X <- X + matrix(rnorm(2500, sd = 0.1), nrow(X), ncol(X))
gi <- get_GI_network(minigwas, snpMapping = minisnpMapping, ppi = minippi)
scones_(X, minigwas[['fam']]$affected, minigwas[['map']]$snp, gi, 10, 1)

hclimente/martini documentation built on Feb. 26, 2024, 6:23 p.m.