kaiqiong/SOMNiBUS: Smooth modeling of bisulfite sequencing

This package aims to analyse count-based methylation data on predefined genomic regions, such as those obtained by targeted sequencing, and thus to identify differentially methylated regions (DMRs) that are associated with phenotypes or traits. The method is built a rich flexible model that allows for the effects, on the methylation levels, of multiple covariates to vary smoothly along genomic regions. At the same time, this method also allows for sequencing errors and can adjust for variability in cell type mixture.

Getting started

Package details

Bioconductor views DNAMethylation DifferentialMethylation Epigenetics FunctionalPrediction Regression Sequencing
MaintainerAudrey Lema├žon <audrey@mims.ai>
LicenseMIT + file LICENSE
URL https://github.com/kaiqiong/SOMNiBUS
Package repositoryView on GitHub
Installation Install the latest version of this package by entering the following in R:
kaiqiong/SOMNiBUS documentation built on Feb. 24, 2023, 5:38 a.m.