bioplex_table: BioPlex protein-protein interactions

In lagelab/Genoppi: genoppi

BioPlex protein-protein interactions

Description

A dataset containing 118,162 protein-protein interactions in BioPlex 3.0, identified through AP-MS of 10,128 human bait proteins in HEK293T cells.

Usage

bioplex_table

Format

A data.frame with 883,356 rows and 4 variables:

Gene1

HGNC gene symbol of first protein (bait)

Gene2

HGNC gene symbol of second protein (prey)

pW

Probability that the prey is a wrong identification

pNI

Probability of the prey is a background protein

pInt

Probability of the prey is a high-confidence interacting protein

Source

BioPlex data (v3.0) downloaded on 2021-01-04 from: https://bioplex.hms.harvard.edu/interactions.php

References

Huttlin EL, Ting L, Bruckner RJ, et al. The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015;162(2):425-440. doi:10.1016/j.cell.2015.06.043

Huttlin EL, Bruckner RJ, Navarrete-Perea J, et al. Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome. bioRxiv. 2020. doi:10.1101/2020.01.19.905109

See Also

Other datasets: accession_gene_table, example_data2, example_data3, example_data, genes_snps, gnomad_table, goa_bp_table, goa_cc_table, goa_mf_table, gtex_protein, gtex_rna, gwas_table, hgnc_group_table, hpa_rna, inweb_table, irefindex_table, msigdb_c1_table, msigdb_c2_table, msigdb_c3_table, msigdb_c4_table, msigdb_c5_table, msigdb_c6_table, msigdb_c7_table, msigdb_h_table

lagelab/Genoppi documentation built on Oct. 13, 2022, 2:36 p.m.