Description Usage Arguments Value
View source: R/doKEGGEnrichment.R
Perform KEGG enrichment analysis using cluster profiler.
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 | doEnrichKEGG(
rca.obj,
annotation = NULL,
org = "hsa",
key = "kegg",
p.Val = 0.05,
q.Val = 0.2,
p.Adjust.Method = "BH",
gene.label.type = "SYMBOL",
filename = "KEGG_Enrichment.pdf",
background.set = "ALL",
background.set.threshold = NULL,
n.Cells.Expressed = NULL,
cluster.ID = NULL,
deep.split = NULL
)
|
rca.obj |
An RCA2 object |
annotation |
An ontology dataset that can be obtained from bioconductor. Used for ID matching. |
org |
Supported organism in KEGG. An overview is listed in 'http://www.genome.jp/kegg/catalog/org_list.html'. Default: hsa (human) |
key |
one of "kegg", 'ncbi-geneid', 'ncib-proteinid' and 'uniprot', Default: KEGG. |
p.Val |
p-value cut-off, default 0.05 |
q.Val |
q-value cut-off, default 0.2 |
p.Adjust.Method |
p-value adjustment method to be used, default BH |
gene.label.type |
Type of gene.labels used, default SYMBOL |
filename |
postfix of the plots generated, GoEnrichment.pdf |
background.set, |
ALL indicates that all genes are considered, CLUSTER indicates that only genes with the cluster of interest are considered (default: ALL) |
background.set.threshold, |
minimum expression threshold used for mean gene-expression. Either a numerical value or one of the following thresholds computed on the mean gene-expression values across all genes within a considered cluster: Min, 1stQ, Mean, Median, 3rdQ. Default: NULL |
n.Cells.Expressed |
Alternative threshold to filter genes. Keep only genes that are expressed in at least n.Cells.Expressed cells |
cluster.ID |
ID of a cluster for which the GO enrichment should be computed. If this is not provided, enrichment will be computed for all clusters. Default: NULL |
deep.split |
Deep.split to be used if hierachical clustering was used to cluster the projection |
RCA object.
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