fit_drc_score_by_dose: DRC 4-param dose response fits with bottom fixed = 0

In momeara/MPStats: Tools for analyzing Morphological Profiling data

DRC 4-param dose response fits with bottom fixed = 0

Description

Use the R drc package to fit dose response data

Usage

fit_drc_score_by_dose(well_scores)

Arguments

well_scores

tibble::tibble as output by read_well_scores

Details

The model that is fit is the 4-parameter sigmoid with bottom fixed at 0. To fit the curve, drc uses weighted least squares. Assuming errors are not correlated the BLUE has weight w_i = 1/V_i, where V_i is the variance of the bayesian probability positive estimator using a prior of Beta(10,10) and then normalized so each replica has on average weight 1.

Value

data.frame with information about fits

momeara/MPStats documentation built on July 19, 2022, 3:34 p.m.