generate_MuSyC_effects: Drug Synergy MuSyC Drug Synergy model

In momeara/MPStats: Tools for analyzing Morphological Profiling data

Drug Synergy MuSyC Drug Synergy model

Description

Assume that the response metric decreases with more effective drugs Let E3 be the effect at the maximum concentration of both drugs

Usage

generate_MuSyC_effects(d1, d2, E0, s1, C1, E1, s2, C2, E2, alpha, E3)

Arguments

d1	Dose of drug 1
d2	Dose of drug 2
E0	effect with no drug treatment # params for drug 1 by it self
s1	drug 1 hill slope
C1	drug 1 EC50
E1	drug 1 maximum effect # params for drug 2 by it self
s2	drug 2 hill slope
C2	drug 2 EC50
E2	drug 2 maximum effect
beta	synergistic efficacy percent increase in a drug combination’s effect beyond the most efficacious single drug. beta > 0 => synergistic efficacy the effect at the maximum concentration of both drugs (E3) exceeds the maximum effect of either drug alone (E1 or E2) beta < 0 => antagonistic efficacy at least one or both drugs are more efficacious as single agents than in combination
alpha1	synergistic potency how the effective dose of drug 1 is altered by the presence of drug 2
alpha2	synergistic potency how the effective dose of drug 2 is altered by the presence of drug 1 alpha > 1 => synergistic potency the EC50 decreases because of the addition of the other drug, corresponding to an increase in potency 0 <= alpha < 1 => antagonistic potency the EC50 of the drug increases as a result of the other drug, corresponding to a decrease in potency alpha1 == alpha2 if detailed balance

Details

Special cases: * dose additive model: alpha1 = alpha2 = 0 * loewe: h1 = h2 = 1 * CI: E0 = 1, E1 = E2 = E3 = 0 the drug effect is equated with percent inhibition * bliss drug independence model: E0 = 1, E1 = E2 = E3 = 0, alpha1 = alpha2 = 1

momeara/MPStats documentation built on July 19, 2022, 3:34 p.m.