Description Usage Arguments Examples
Runs the TCGAome analysis pipeline on the given tumor types.
1 2 3 4 5 6 | run_TCGAome(tumor_types, run_pca_analysis = TRUE,
run_hclust_analysis = FALSE, run_rgcca = FALSE, run_rcca = FALSE,
topN = 5, spls_selection_method = "loadings",
GO_similarity_measure = "Wang", GOA_search_universe = "human",
enrichment_significance_thr = 0.01, GO_ontology = "BP",
multiple_test_adjustment = FALSE)
|
tumor_types |
Vector of tumor types to be analyzed from those available at TCGA (run RTCGAToolbox::getFirehoseDatasets() to see all available types) |
run_pca_analysis |
Flag indicating if the PCA should run, this is part of the data pre-analysis (default: TRUE) |
run_hclust_analysis |
Flag indicating if the hierarchical clustering analysis should run, this is part of the data pre-analysis (default: FALSE) |
run_rgcca |
Flag indicating if the Regularized Generalized Canonical Correlation Analysis (RGCCA) should run (default: FALSE). Beware that this analysis is not intended for datasets with number of variables >> number of samples. |
run_rcca |
Flag indicating if the Regularized Canonical Correlation Analysis (rCCA) should run (default: FALSE). Beware that this analysis is not intended for datasets with number of variables >> number of samples. |
topN |
Indicates the top number of variables to select on MCIA and sPLS results (default: 5). It will select N variables on each of the data types, on each of the three first components and on each extreme of range, that is a maximum of 2*3*2*N, considering that there might be overlap between components. |
spls_selection_method |
Indicates the method for variable selection on sPLS results. One of 'correlation' or 'loadings' (default: 'loadings'). Loadings method will choose those variables maximizing variance across the samples, while correlation method will choose those variables with a higher correlation with other variables, that is those variables more distant to the origin in the correlation plot. |
GO_similarity_measure |
The similarity measured employed to cluster and visualize GO terms, one in 'Resnik', 'Lin', 'Rel', 'Jiang', 'Wang', 'UI', 'binary', 'bray-curtis', 'cosine', 'all' (default: 'Wang') |
GOA_search_universe |
The GOA universe to use in functional similarity measures (i.e.: only aplicable to 'binary', 'bray-curtis', 'cosine', 'UI'), one in 'human', 'uniprot', 'gene_list' (default: 'human') |
enrichment_significance_thr |
The threshold to consider a GO enrichment result as significant (default: 0.01) |
GO_ontology |
The GO ontology on which to perform the enrichment, one of 'BP', 'MF', 'CC' (default: BP) |
multiple_test_adjustment |
Flag to run multiple test adjustment on GO enrichment results (default: F) |
1 | run_TCGAome(c('BRCA', 'OV'))
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