dot-methylcc_estep: Expectation step

In stephaniehicks/methylCC: Estimate the cell composition of whole blood in DNA methylation samples

Expectation step

Description

Expectation step in EM algorithm for methylCC

Usage

.methylcc_estep(Ys, Zs, current_pi_mle, current_theta, meth_status = 0)

Arguments

Ys	observed methylation levels in samples provided by user of dimension R x n
Zs	Cell type specific regions of dimension R x K
current_pi_mle	cell composition MLE estimates of dimension K x n
current_theta	other parameter estimates in EM algorithm
meth_status	Indicator function corresponding to regions that are unmethylated (meth_status=0) or methylated (meth_status=1)

Value

List of expected value of the first two moments of the random effects (or the E-Step in the EM algorithm) used in .methylcc_engine()

stephaniehicks/methylCC documentation built on Nov. 6, 2022, 5:51 p.m.