dot-methylcc_mstep: Maximization step

In stephaniehicks/methylCC: Estimate the cell composition of whole blood in DNA methylation samples

Maximization step

Description

Maximization step in EM Algorithm for methylCC

Usage

.methylcc_mstep(Ys, Zs, current_pi_mle, current_theta, estep0, estep1)

Arguments

Ys	observed methylation levels in samples provided by user of dimension R x n
Zs	Cell type specific regions of dimension R x K
current_pi_mle	cell composition MLE estimates of dimension K x n
current_theta	other parameter estimates in EM algorithm
estep0	Results from expectation step for unmethylated regions
estep1	Results from expectation step for methylated regions

Value

A list of the updated MLEs (or the M-Step in the EM algorithm) used in .methylcc_engine()

stephaniehicks/methylCC documentation built on Nov. 6, 2022, 5:51 p.m.