postImputeFilter: Apply quality filters after imputation by Beagle5.0

In wolfemd/genomicMateSelectR: Genomic Mate Selection

Apply quality filters after imputation by Beagle5.0

Description

Remove markers from the imputed VCF based on adjustable thresholds. For VCFs imputed by Beagle5

Usage

postImputeFilter(
  inPath = NULL,
  inName,
  outPath = NULL,
  outName,
  DR2thresh = 0.75,
  HWEthresh = 1e-20,
  MAFthresh = 0.005
)

Arguments

inPath	path to input VCFs
inName	imputed input VCF name
outPath	path for output to be written to
outName	name desired, don't add file suffix, will be *.vcf.gz
DR2thresh	remove if imputation quality score DR2 supplied in the VCF INFO field by Beagle is less than or equal to the threshold
HWEthresh	remove if p-value HWE from vcftools --hardy less than threshold, smaller p-value means more departure from HWE
MAFthresh	remove if minor allele frequency less than threshold

Details

Uses vcftools and R. of minor allee frequency MAFthresh, p-value measuring likelihood of divergence from hardy-weinberg equilibrium ()

NOTICE: This function is part of a family of functions ("imputation_functions") developed as part of the NextGen Cassava Breeding Project genomic selection pipeline. For some examples of their useage:

• IITA_2021GS (should be first use of this package)

• NRCRI_2021GS

• TARI_2020GS

See Also

Other imputation_functions: convertDart2vcf(), convertVCFtoDosage(), createGenomewideDosage(), filter_positions(), mergeVCFs(), postImputeFilterBeagle4pt1(), runBeagle4pt1GL(), runBeagle5(), splitVCFbyChr()

wolfemd/genomicMateSelectR documentation built on July 1, 2022, 10:42 p.m.