Description Arguments Details Value Author(s) References
Quantile normalize betas from exprmethy450 objects
bn |
An exprmethy450 object. |
fudge |
value added to total intensity to prevent denominators close to zero when calculating betas |
betaqn quantile normalizes betas
exprmethy450 object of the same shape and order as bn.
Leonard.Schalkwyk@kcl.ac.uk
[1] Pidsley R, Wong CCY, Volta M, Lunnon K, Mill J, Schalkwyk LC: A data-driven approach to preprocessing Illumina 450K methylation array data (submitted)
[2] Dedeurwaerder S, Defrance M, Calonne E, Sotiriou C, Fuks F: Evaluation of the Infinium Methylation 450K technology . Epigenetics 2011, 3(6):771-784.
[3] Touleimat N, Tost J: Complete pipeline for Infinium R Human Methylation 450K BeadChip data processing using subset quantile normalization for accurate DNA methylation estimation. Epigenomics 2012, 4:325-341
[4] Maksimovic J, Gordon L, Oshlack A: SWAN: Subset quantile Within-Array Normalization for Illumina Infinium HumanMethylation450 BeadChips. Genome biology 2012, 13(6):R44
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