Nothing
intraMLE <-
function(d,n,B=0,DB=c(0,0),JC=FALSE,CI=0,CI_Boot,type="bca", plot=FALSE){
Res2=list()
if(is.numeric(d)){d=d}else{stop("d is not numeric")}
if(is.numeric(n)){n=n}else{stop("n is not numeric")}
if(B==0&& plot==TRUE){stop("please select a number of bootstrap repititions for the plot")}
if(B%%1==0){B=B}else{stop("B is not an integer")}
if(DB[1]%%1==0 && DB[2]%%1==0 ){DB=DB}else{stop("At least one entry in DB is not an integer")}
if(length(d)==length(n)){}else{stop("Input vectors do not have the same length")}
estimate=function(d,n,CI){
if(CI==0){nll=function(rho){
integral=NULL
simpson <- function(fun, a, b, n=700) {
h <- (b-a)/n
x <- seq(a, b, by=h)
if (n == 2) {
s <- fun(x[1]) + 4*fun(x[2]) +fun(x[3])
} else {
s <- fun(x[1]) + fun(x[n+1]) + 2*sum(fun(x[seq(2,n,by=2)])) + 4 *sum(fun(x[seq(3,n-1, by=2)]))
}
s <- s*h/3
return(s)
}
ll=0
d1=d/n
PD1=mean(d1)
for(i in 1:length(d)){
d1i=d[i]
n1i=n[i]
integrand=function(x){
condPD <- pnorm((qnorm(PD1) - sqrt(rho) * x) / sqrt(1 - rho));
return (choose(n1i, d1i) * (condPD^d1i) * ((1 - condPD)^(n1i - d1i)) * dnorm(x));
}
integral[i]=simpson(integrand,-10,10,n=10000)
if(is.na(integral[i])){integral[i]=1}
ll=ll+log(integral[i])
}
return(-ll)
}
Est<-list(Original =optimise(nll, interval = c(0, 1), maximum = FALSE)$minimum)
}else{
nll=function(rho){
integral=NULL
simpson <- function(fun, a, b, n=700) {
h <- (b-a)/n
x <- seq(a, b, by=h)
if (n == 2) {
s <- fun(x[1]) + 4*fun(x[2]) +fun(x[3])
} else {
s <- fun(x[1]) + fun(x[n+1]) + 2*sum(fun(x[seq(2,n,by=2)])) + 4 *sum(fun(x[seq(3,n-1, by=2)]))
}
s <- s*h/3
return(s)
}
ll=0
d1=d/n
PD1=mean(d1)
for(i in 1:length(d)){
d1i=d[i]
n1i=n[i]
integrand=function(x){
condPD <- pnorm((qnorm(PD1) - sqrt(rho) * x) / sqrt(1 - rho));
return (choose(n1i, d1i) * (condPD^d1i) * ((1 - condPD)^(n1i - d1i)) * dnorm(x));
}
integral[i]=simpson(integrand,-10,10,n=10000)
if(is.na(integral[i])){integral[i]=1}
ll=ll+log(integral[i])
}
return(-ll)
}
Res1<- optimise(nll, interval = c(0, 1), maximum = FALSE)$minimum
hessian1<-hessian(nll,Res1)
SD<- 1/sqrt(hessian1)
CI<- 1-(1-CI)/2
Est<-list(Original =Res1, CI=c(Res1-qnorm(CI)*SD,Res1+qnorm(CI)*SD))
}
}
Estimate_Standard<- estimate(d,n,CI)
######
if(DB[1]!=0){
IN=DB[1]
OUT=DB[2]
theta1=NULL
theta2=matrix(ncol = OUT, nrow=IN)
for(i in 1:OUT){
N<-length(d)
Ib<-sample(N,N,replace=TRUE) ## sampling with replacement
d_o<-d[Ib]
n_o<-n[Ib]
try(theta1[i]<-estimate(d_o,n_o,CI)$Original, silent = TRUE)
for(c in 1:IN){
Ic<-sample(N,N,replace=TRUE) ## sampling with replacement
d_i<-d_o[Ic]
n_i<-n_o[Ic]
try( theta2[c,i]<-estimate(d_i,n_i,CI)$Original, silent = TRUE)
}
}
Boot1<- mean(theta1, na.rm = TRUE)
Boot2<- mean(theta2, na.rm = TRUE)
BC<- 2*Estimate_Standard$Original -Boot1
DBC<- (3*Estimate_Standard$Original-3*Boot1+Boot2)
Estimate_DoubleBootstrap<-list(Original = Estimate_Standard$Original, Bootstrap=BC, Double_Bootstrap=DBC, oValues=theta1, iValues=theta2)
}
if(B>0){
N<-length(n)
D<- matrix(ncol=1, nrow=N,d)
BCA=function(data,n, indices){
d <- data[indices,]
n<-n[indices]
tryCatch(estimate(d,n,CI)$Original,error=function(e)NA)
}
boot1<- boot(data = D, statistic = BCA, n=n, R=B)
Estimate_Bootstrap<-list(Original = boot1$t0, Bootstrap=2*boot1$t0 - mean(boot1$t,na.rm = TRUE),bValues=boot1$t )
if(missing(CI_Boot)){Estimate_Bootstrap=Estimate_Bootstrap}else{
if(type=="norm"){Conf=(boot.ci(boot1,conf=CI_Boot,type = type)$normal[2:3])}
if(type=="basic"){Conf=(boot.ci(boot1,conf=CI_Boot,type = type)$basic[4:5])}
if(type=="perc"){Conf=(boot.ci(boot1,conf=CI_Boot,type = type))$percent[4:5]}
if(type=="bca"){Conf=(boot.ci(boot1,conf=CI_Boot,type = type))$bca[4:5]}
if(type=="all"){Conf=(boot.ci(boot1,conf=CI_Boot,type = type))}
CI=CI_Boot
nll=function(rho){
integral=NULL
simpson <- function(fun, a, b, n=700) {
h <- (b-a)/n
x <- seq(a, b, by=h)
if (n == 2) {
s <- fun(x[1]) + 4*fun(x[2]) +fun(x[3])
} else {
s <- fun(x[1]) + fun(x[n+1]) + 2*sum(fun(x[seq(2,n,by=2)])) + 4 *sum(fun(x[seq(3,n-1, by=2)]))
}
s <- s*h/3
return(s)
}
ll=0
d1=d/n
PD1=mean(d1)
for(i in 1:length(d)){
d1i=d[i]
n1i=n[i]
integrand=function(x){
condPD <- pnorm((qnorm(PD1) - sqrt(rho) * x) / sqrt(1 - rho));
return (choose(n1i, d1i) * (condPD^d1i) * ((1 - condPD)^(n1i - d1i)) * dnorm(x));
}
integral[i]=simpson(integrand,-10,10,n=10000)
if(is.na(integral[i])){integral[i]=1}
ll=ll+log(integral[i])
}
return(-ll)
}
Res1<- optimise(nll, interval = c(0, 1), maximum = FALSE)$minimum
hessian1<-hessian(nll,Res1)
SD<- 1/sqrt(hessian1)
CI<- 1-(1-CI)/2
CI1=c(Res1-qnorm(CI)*SD,Res1+qnorm(CI)*SD)
Estimate_Bootstrap<-list(Original = boot1$t0, Bootstrap=2*boot1$t0 - mean(boot1$t,na.rm = TRUE),CI=CI1,CI_Boot=Conf,bValues=boot1$t )
}
if(plot==TRUE){
Dens<-density(boot1$t, na.rm = TRUE)
XY<-cbind(Dens$x,Dens$y)
label<-data.frame(rep("Bootstrap density",times=length(Dens$x)))
Plot<-cbind(XY,label)
colnames(Plot)<-c("Estimate","Density","Label")
SD<-cbind(rep(boot1$t0,times=length(Dens$x)), Dens$y,rep("Standard estimate",times=length(Dens$x)))
colnames(SD)<-c("Estimate","Density","Label")
BC<-cbind(rep(Estimate_Bootstrap$Bootstrap,times=length(Dens$x)), Dens$y,rep("Bootstrap corrected estimate",times=length(Dens$x)))
colnames(BC)<-c("Estimate","Density","Label")
Plot<-rbind(Plot,SD, BC)
Plot$Estimate<-as.numeric(Plot$Estimate)
Plot$Density<- as.numeric(Plot$Density)
Estimate<-Plot$Estimate
Density<-Plot$Density
Label<-Plot$Label
P<-ggplot()
P<-P+with(Plot, aes(x=Estimate, y=Density, colour=Label)) +
geom_line()+
scale_colour_manual(values = c("black", "red", "orange"))+
theme_minimal(base_size = 15) +
ggtitle("Bootstrap Density" )+
theme(plot.title = element_text(hjust = 0.5),legend.position="bottom",legend.text = element_text(size = 12),legend.title = element_text( size = 12), legend.justification = "center",axis.text.x= element_text(face = "bold", size = 12))
print(P)
}
}
if(JC==TRUE){
N=length(d)
Test=NULL
for(v in 1:N){
d2<-d[-v]
n2<-n[-v]
try(Test[v]<-estimate(d2,n2,CI)$Original)
}
Estimate_Jackknife<-list(Original = Estimate_Standard$Original, Jackknife=(N*Estimate_Standard$Original-(N-1)*mean(Test)))
}
if(B>0){return(Estimate_Bootstrap)}
if(JC==TRUE){return(Estimate_Jackknife)}
if(DB[1]!=0){return(Estimate_DoubleBootstrap)}
if(B==0 && JC==FALSE && DB[1]==0){return(Estimate_Standard)}
}
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