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Copula Mixed Models for Multivariate Meta-Analysis of Diagnostic Test Accuracy Studies

Description

Fits copula mixed models for multivariate meta-analysis of diagnostic test accuracy studies proposed in Nikoloulopoulos (2015, 2017, 2018a, 2018b, 2019, 2020a, 2020b, 2022, 2024a, 2024b).

Details

This package contains R functions to implement:

• The copula mixed model for meta-analysis of diagnostic test accuracy studies and produce SROC curves and summary operating points (a pair of average sensitivity and specificity) with a confidence region and a predictive region (Nikoloulopoulos, 2015, 2018a). All the analyses presented in Section 7 of Nikoloulopoulos (2015) are given as code examples in the package;

• The vine copula mixed model for meta-analysis of diagnostic test accuracy studies accounting for disease prevalence and non-evaluable subjects (Nikoloulopoulos, 2017, 2020a);

• The hybrid vine copula mixed model for meta-analysis of diagnostic test accuracy case-control and cohort studies (Nikoloulopoulos, 2018b);

• The D-vine copula mixed model for meta-analysis and comparison of two diagnostic tests (Nikoloulopoulos, 2019).

• The multinomial quadrivariate D-vine copula mixed model for diagnostic studies meta-analysis accounting for non-evaluable subjects (Nikoloulopoulos, 2020b).

• The one-factor copula mixed model for joint meta-analysis of multiple diagnostic tests (Nikoloulopoulos, 2022).

• The multinomial six-variate D-vine copula mixed model for for meta-analysis of two diagnostic tests accounting for within and between studies dependence (Nikoloulopoulos, 2024a).

• The 1-truncated D-vine copula mixed model for for meta-analysis of diagnostic test accuracy studies without a gold standard (Nikoloulopoulos, 2024b).

Author(s)

Aristidis K. Nikoloulopoulos.

References

Nikoloulopoulos, A.K. (2015) A mixed effect model for bivariate meta-analysis of diagnostic test accuracy studies using a copula representation of the random effects distribution. Statistics in Medicine, 34, 3842–3865. \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1002/sim.6595")}.

Nikoloulopoulos, A.K. (2017) A vine copula mixed effect model for trivariate meta-analysis of diagnostic test accuracy studies accounting for disease prevalence. Statistical Methods in Medical Research, 26, 2270–2286. \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1177/0962280215596769")}.

Nikoloulopoulos, A.K. (2018a) On composite likelihood in bivariate meta-analysis of diagnostic test accuracy studies. AStA Advances in Statistical Analysis, 102, 211–227. \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1007/s10182-017-0299-y")}.

Nikoloulopoulos, A.K. (2018b) Hybrid copula mixed models for combining case-control and cohort studies in meta-analysis of diagnostic tests. Statistical Methods in Medical Research, 27, 2540–2553. \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1177/0962280216682376")}.

Nikoloulopoulos, A.K. (2019) A D-vine copula mixed model for joint meta-analysis and comparison of diagnostic tests. Statistical Methods in Medical Research, 28(10-11):3286–3300. \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1177/0962280218796685")}.

Nikoloulopoulos, A.K. (2020a) An extended trivariate vine copula mixed model for meta-analysis of diagnostic studies in the presence of non-evaluable outcomes. The International Journal of Biostatistics, 16(2). \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1515/ijb-2019-0107")}.

Nikoloulopoulos, A.K. (2020b) A multinomial quadrivariate D-vine copula mixed model for diagnostic studies meta-analysis in the presence of non-evaluable subjects. Statistical Methods in Medical Research, 29 (10), 2988–3005. \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1177/0962280220913898")}.

Nikoloulopoulos, A.K. (2022) An one-factor copula mixed model for joint meta-analysis of multiple diagnostic tests. Journal of the Royal Statistical Society: Series A (Statistics in Society), 185 (3), 1398–1423. \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1111/rssa.12838")}.

Nikoloulopoulos, A.K. (2024a) Joint meta-analysis of two diagnostic tests accounting for within and between studies dependence. Statistical Methods in Medical Research. \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1177/09622802241269645")}.

Nikoloulopoulos, A.K. (2024b) Vine copula mixed models for meta-analysis of diagnostic accuracy studies without a gold standard. Submitted.

CopulaREMADA documentation built on Oct. 18, 2024, 1:08 a.m.