MVcML_SdTheta: Standard error estimate for MVMR-cML-BIC

In MendelianRandomization: Mendelian Randomization Package

Standard error estimate for MVMR-cML-BIC

Description

This is based on the profile likelihood of the set of valid IVs, which is not robust to uncertainty in model selection.

Usage

MVcML_SdTheta(b_exp, b_out, Sig_inv_l, theta, zero_ind, r_vec = NULL)

Arguments

b_exp	A matrix of SNP effects on the exposure variable.
b_out	A vector of SNP effects on the outcome variable.
Sig_inv_l	A list of inverse of covariance matrix.
theta	A vector of final estimates of causal effect of each exposure by MVMR-cML-BIC obtained from MVmr_cML_DP.
zero_ind	A vector of the index of valid IVs.
r_vec	A vector of estimated horizontal pleiotropic effects.

Value

A vector

MendelianRandomization documentation built on Aug. 9, 2023, 1:05 a.m.