MVcML_SdTheta: Standard error estimate for MVMR-cML-BIC
In MendelianRandomization: Mendelian Randomization Package

MVcML_SdTheta

R Documentation

Standard error estimate for MVMR-cML-BIC

This is based on the profile likelihood of the set of valid IVs, which is not robust to uncertainty in model selection.

MVcML_SdTheta(b_exp, b_out, Sig_inv_l, theta, zero_ind, r_vec = NULL)

`b_exp`	A matrix of SNP effects on the exposure variable.
`b_out`	A vector of SNP effects on the outcome variable.
`Sig_inv_l`	A list of inverse of covariance matrix.
`theta`	A vector of final estimates of causal effect of each exposure by MVMR-cML-BIC obtained from `MVmr_cML_DP`.
`zero_ind`	A vector of the index of valid IVs.
`r_vec`	A vector of estimated horizontal pleiotropic effects.