snp_pcadapt: Outlier detection

In bigsnpr: Analysis of Massive SNP Arrays

Outlier detection

Description

Method to detect genetic markers involved in biological adaptation. This provides a statistical tool for outlier detection based on Principal Component Analysis. This corresponds to the statistic based on mahalanobis distance, as implemented in package pcadapt.

Usage

snp_pcadapt(
  G,
  U.row,
  ind.row = rows_along(G),
  ind.col = cols_along(G),
  ncores = 1
)

bed_pcadapt(
  obj.bed,
  U.row,
  ind.row = rows_along(obj.bed),
  ind.col = cols_along(obj.bed),
  ncores = 1
)

Arguments

G	A FBM.code256 (typically ⁠<bigSNP>$genotypes⁠). You shouldn't have missing values. Also, remember to do quality control, e.g. some algorithms in this package won't work if you use SNPs with 0 MAF.
U.row	Left singular vectors (not scores, U^T U = I) corresponding to ind.row.
ind.row	An optional vector of the row indices (individuals) that are used. If not specified, all rows are used. Don't use negative indices.
ind.col	An optional vector of the column indices (SNPs) that are used. If not specified, all columns are used. Don't use negative indices.
ncores	Number of cores used. Default doesn't use parallelism. You may use bigstatsr::nb_cores().
obj.bed	Object of type bed, which is the mapping of some bed file. Use obj.bed <- bed(bedfile) to get this object.

Value

An object of classes mhtest and data.frame returning one score by SNP. See methods(class = "mhtest").

References

Luu, K., Bazin, E., & Blum, M. G. (2017). pcadapt: an R package to perform genome scans for selection based on principal component analysis. Molecular ecology resources, 17(1), 67-77.

See Also

snp_manhattan, snp_qq and snp_gc.

Examples

test <- snp_attachExtdata()
G <- test$genotypes
obj.svd <- big_SVD(G, fun.scaling = snp_scaleBinom(), k = 10)
plot(obj.svd) # there seems to be 3 "significant" components
pcadapt <- snp_pcadapt(G, obj.svd$u[, 1:3])
snp_qq(pcadapt)

bigsnpr documentation built on Sept. 30, 2024, 9:18 a.m.