Man pages for dfped
Extrapolation and Bridging of Adult Information in Early Phase Dose-Finding Paediatrics Studies

albAgeConcentration of albumin according to age.
alpha1AGageConcentration of alpha1-acid glycoprotein according to age.
CladuClearance of the unbound fraction of a specific molecule for...
Clch.AlloPaediatric clearance according to the allometry adjustment...
Clch.LinearPaediatric clearance according to the linear adjustment (LA)...
Clch.MatPaediatric clearance according to the maturation adjustment...
ClchuClearance of the unbound fraction of a specific molecule for...
concAdConcentration of a specific molecule in plasma for the adult...
concChConcentration of a specific molecule in plasma for the...
dfped-packageExtrapolation and Bridging of Adult Information in Early...
doseChoiceChoice of the next given dose level.
doseRangeDose-range for the paediatric population according to adult...
FchPaediatric bioavailability according to age.
fuChUnbound fraction of the molecule in the plasma for children.
KCYP1A2Fraction of adult CYP1A2 abundance according to age.
KCYP2B6Fraction of adult CYP2B6 abundance according to age.
KCYP2C18_19Fraction of adult CYP2C18/CYP2C19 abundance according to age.
KCYP2C8Fraction of adult CYP2C8 abundance according to age.
KCYP2C9Fraction of adult CYP2C9 abundance according to age.
KCYP2D6Fraction of adult CYP2D6 abundance according to age.
KCYP2E1Fraction of adult CYP2E1 abundance according to age.
KCYP3AFraction of adult CYP3A abundance according to age.
KCYP3A4_5Fraction of adult CYP3A4/CYP3A5 abundance according to age.
kickoffControlControl for presence of at least toxicities and efficacies...
metaPhaseMeta-analysis function of dose-finding studies proposed by...
priorChoiceDecision function for the choice of variance (sigmaHI or...
sigmaEssThe variance of the effective sample size (ESS).
sigmaHICompute the informative prior variance for the adaptive...
sigmaLICompute the least informative prior variance for the adaptive...
simuA simulation of a single dose-finding trials in paediatrics.
simulationSimulate one or "n" dose-finding trials in paediatrics.
skeletonBuild a working model.
waicFunction for the Watanabe-Akaike information criteria (WAIC)
weightCYPsumProportion of the molecule metabolised by the CYPs for a...
dfped documentation built on Aug. 1, 2017, 9:02 a.m.