kickoffControl: Control for presence of at least toxicities and efficacies...

In dfped: Extrapolation and Bridging of Adult Information in Early Phase Dose-Finding Paediatrics Studies

Description

An algorithm that control if we have at least one 0 and one 1 for both efficacy and toxicity.

Usage

kickoffControl(tox, currentDose, cohortSize, nbDoses)

Arguments

tox	The vector of toxicity outcomes.
currentDose	The current dose of a patient.
cohortSize	The size of the cohort; must be integer.
nbDoses	The maximum number of the doses.

Author(s)

Artemis Toumazi [e-mail], Caroline Petit [e-mail], Sarah Zohar [e-mail]

References

Petit, C., et al, (2016) Unified approach for extrapolation and bridging of adult information in early phase dose-finding paediatric studies, Statistical Methods in Medical Research, <doi:10.1177/0962280216671348>.

Examples

## Not run: 
	tox <- c(0.1301477, 0.2774171, 0.4184642, 0.6486846, 0.8257219)
	currentDose <- 3
	cohortSize <- 1
	nbDoses <- 5 
	kickoffControl(tox, currentDose, cohortSize, nbDoses)

## End(Not run)

dfped documentation built on May 2, 2019, 8:36 a.m.