Description Usage Arguments Author(s) References See Also Examples
Proportion of the molecule metabolised by the CYPs. A weighted sum is computed. For each CYP, the proportion metabolised in adults is multiplied with the fraction of CYP (KCYP) available for a child according to age.
1 | weightCYPsum(age, percCYP)
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age |
The age of child. |
percCYP |
Dataframe giving the percentage of the molecule metabolised for each cytochrome in adults. Dataframe with two column - column 1: CYP name, column 2: percentage of the molecule metabolised. |
Artemis Toumazi artemis.toumazi@gmail.com, Caroline Petit caroline.petit@crc.jussieu.fr, Sarah Zohar sarah.zohar@inserm.fr
Petit, C., et al, (2016) Unified approach for extrapolation and bridging of adult information in early phase dose-finding paediatric studies, Statistical Methods in Medical Research, <doi:10.1177/0962280216671348>.
1 2 3 | age <- 2
perc_CYP <- data.frame("CYP3A4_5" = 0.7, "CYP1A2" = 0.3)
weightCYPsum(age, perc_CYP)
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