Description Usage Arguments Author(s) References See Also Examples
Unbound fraction of the molecule in the plasma for children.
1 | fuCh(age, fuAd, percAlb, percAlpha1AG)
|
age |
The age of children. |
fuAd |
Unbound fraction of the molecule in adults. |
percAlb |
Percentage of the molecule binding with albumin. |
percAlpha1AG |
Percentage of the molecule binding with alpha1-acid glycoprotein. |
Artemis Toumazi artemis.toumazi@gmail.com, Caroline Petit caroline.petit@crc.jussieu.fr, Sarah Zohar sarah.zohar@inserm.fr
Petit, C., et al, (2016) Unified approach for extrapolation and bridging of adult information in early phase dose-finding paediatric studies, Statistical Methods in Medical Research, <doi:10.1177/0962280216671348>.
Johnson T., Rostami-Hodjegan A. and Tucker G. (2006) Prediction of clearance of eleven drugs and associated variability in neonates, infants and children, Clin. Pharmacokinet., 45:931-956.
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 | ## Not run:
########
# Note: For this example we are using a paediatric database that we have including data of
# children from 0 to 19 years old.
########
children <- read.csv("/Users/artemistoumazi/paediatric_data_p3m/children_0_19.csv")
AGE <- children$Age
fu_ad <- 1
perc_alb <- 1
perc_alpha1AG <- 0
fuCh(AGE, fu_ad, perc_alb, perc_alpha1AG)
## End(Not run)
|
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