concCh: Concentration of a specific molecule in plasma for the...

In dfped: Extrapolation and Bridging of Adult Information in Early Phase Dose-Finding Paediatrics Studies

Description

Compute the concentration of a specific molecule in plasma for the paediatric population according to age, the percentage binding with albumin and alpha1-acid glycoprotein.

Usage

concCh(age, percAlb, percAlpha1AG) 

Arguments

age	The age of children.
percAlb	Percentage of the molecule binding with albumin.
percAlpha1AG	Percentage of the molecule binding with alpha1-acid glycoprotein.

Author(s)

Artemis Toumazi [e-mail], Caroline Petit [e-mail], Sarah Zohar [e-mail]

References

Petit, C., et al, (2016) Unified approach for extrapolation and bridging of adult information in early phase dose-finding paediatric studies, Statistical Methods in Medical Research, <doi:10.1177/0962280216671348>.

Johnson T., Rostami-Hodjegan A. and Tucker G. (2006) Prediction of clearance of eleven drugs and associated variability in neonates, infants and children, Clin. Pharmacokinet., 45:931-956.

See Also

concAd

Examples

## Not run:  
    ########
    # Note: For this example we are using a paediatric database that we have including data of 
    # children from 0 to 19 years old.
    ########

    children <- read.csv("/Users/artemistoumazi/paediatric_data_p3m/children_0_19.csv")
    AGE <- children$Age
    perc_alb <- 1
    perc_alpha1AG <- 0
    concCh(AGE, perc_alb, perc_alpha1AG)

## End(Not run)

dfped documentation built on May 2, 2019, 8:36 a.m.