Cladu: Clearance of the unbound fraction of a specific molecule for...
In dfped: Extrapolation and Bridging of Adult Information in Early Phase Dose-Finding Paediatrics Studies
Description
Usage
Arguments
Author(s)
References
See Also
Examples
Description
Compute the clearance of the unbound fraction of a specific molecule for the adult population.
Usage
1
Cladu(Clad, fuAd, Fad)
Arguments
Clad
The apparent clearance for adults.
fuAd
Unbound bioavailability for adults for the molecule.
Fad
Bioavailability for adults.
Author(s)
Artemis Toumazi artemis.toumazi@gmail.com,
Caroline Petit caroline.petit@crc.jussieu.fr,
Sarah Zohar sarah.zohar@inserm.fr
References
Petit, C., et al, (2016) Unified approach for extrapolation and bridging of adult information in early phase dose-finding paediatric studies, Statistical Methods in Medical Research, <doi:10.1177/0962280216671348>.
See Also
Examples
1
2
3
4
Cl_ad <- 3.95
F_ad <- 0.6
fu_ad <- 1
Cladu(Cl_ad, fu_ad, F_ad)
Example output
Loading required package: rstan
Loading required package: ggplot2
Loading required package: StanHeaders
rstan (Version 2.17.3, GitRev: 2e1f913d3ca3)
For execution on a local, multicore CPU with excess RAM we recommend calling
options(mc.cores = parallel::detectCores()).
To avoid recompilation of unchanged Stan programs, we recommend calling
rstan_options(auto_write = TRUE)
Loading required package: stats4
[1] 2.37
dfped documentation built on May 2, 2019, 8:36 a.m.
R Package Documentation
Browse R Packages
We want your feedback!
Note that we can't provide technical support on individual packages. You should contact the package authors for that.
Description Usage Arguments Author(s) References See Also Examples
Description
Compute the clearance of the unbound fraction of a specific molecule for the adult population.
Usage
1 | Cladu(Clad, fuAd, Fad)
|
Arguments
Clad |
The apparent clearance for adults. |
fuAd |
Unbound bioavailability for adults for the molecule. |
Fad |
Bioavailability for adults. |
Author(s)
Artemis Toumazi artemis.toumazi@gmail.com, Caroline Petit caroline.petit@crc.jussieu.fr, Sarah Zohar sarah.zohar@inserm.fr
References
Petit, C., et al, (2016) Unified approach for extrapolation and bridging of adult information in early phase dose-finding paediatric studies, Statistical Methods in Medical Research, <doi:10.1177/0962280216671348>.
See Also
Examples
1 2 3 4 | Cl_ad <- 3.95
F_ad <- 0.6
fu_ad <- 1
Cladu(Cl_ad, fu_ad, F_ad)
|
Example output
Loading required package: rstan
Loading required package: ggplot2
Loading required package: StanHeaders
rstan (Version 2.17.3, GitRev: 2e1f913d3ca3)
For execution on a local, multicore CPU with excess RAM we recommend calling
options(mc.cores = parallel::detectCores()).
To avoid recompilation of unchanged Stan programs, we recommend calling
rstan_options(auto_write = TRUE)
Loading required package: stats4
[1] 2.37
R Package Documentation
Browse R Packages
We want your feedback!
Note that we can't provide technical support on individual packages. You should contact the package authors for that.
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