Clch.Allo: Paediatric clearance according to the allometry adjustment...

In dfped: Extrapolation and Bridging of Adult Information in Early Phase Dose-Finding Paediatrics Studies

Description

Compute the paediatric clearance according to the allometry adjustment (AA) for a specific age.

Usage

Clch.Allo(age, w, Clad, Wad)

Arguments

age	The age of child.
w	The weight of child.
Clad	Apparent clearance of adult.
Wad	Weight of adult (or average weight in the adult population).

Author(s)

Artemis Toumazi [e-mail], Caroline Petit [e-mail], Sarah Zohar [e-mail]

References

Petit, C., et al, (2016) Unified approach for extrapolation and bridging of adult information in early phase dose-finding paediatric studies, Statistical Methods in Medical Research, <doi:10.1177/0962280216671348>.

Johnson T., Rostami-Hodjegan A. and Tucker G. (2006) Prediction of clearance of eleven drugs and associated variability in neonates, infants and children, Clin. Pharmacokinet., 45:931-956.

See Also

Clch.Linear, Clch.Mat

Examples

## Not run: 
    ########
    # Note: For this example we are using a paediatric database that we have including data of 
    # children from 0 to 19 years old.
    ########

    children <- read.csv("/Users/artemistoumazi/paediatric_data_p3m/children_0_19.csv")
    AGE <- children$Age
    W <- children$Weight
    W_ad <- 70
    Cl_ad <- 3.95

    Clch_allo <- Clch.Allo(AGE, W, Cl_ad, W_ad)

## End(Not run)

dfped documentation built on May 2, 2019, 8:36 a.m.