Description Usage Arguments Author(s) References Examples

Algorithm giving the next dose which is the safe most successful dose (sMSD).

1 | ```
doseChoice(probaTox, probaEff, p, targetTox, givenDose)
``` |

`probaTox` |
The probability of toxicity estimated with STAN model. |

`probaEff` |
The probability of efficacy estimated with STAN model. |

`p` |
The probability of success. |

`targetTox` |
The target of toxicity. |

`givenDose` |
The vector of doses given to patients so far. |

Artemis Toumazi artemis.toumazi@gmail.com, Caroline Petit caroline.petit@crc.jussieu.fr, Sarah Zohar sarah.zohar@inserm.fr

Petit, C., et al, (2016) Unified approach for extrapolation and bridging of adult information in early phase dose-finding paediatric studies, Statistical Methods in Medical Research, <doi:10.1177/0962280216671348>.

1 2 3 4 5 6 7 | ```
r <- 0.10
q <- 0.17
p <- 0.9
targetTox <- 0.6
givenDose <- 2
newDose <- doseChoice(r, q, p, targetTox, givenDose)
newDose
``` |

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