doseChoice: Choice of the next given dose level.
In dfped: Extrapolation and Bridging of Adult Information in Early Phase Dose-Finding Paediatrics Studies
Description
Usage
Arguments
Author(s)
References
Examples
Description
Algorithm giving the next dose which is the safe most successful dose (sMSD).
Usage
1
doseChoice(probaTox, probaEff, p, targetTox, givenDose)
Arguments
probaTox
The probability of toxicity estimated with STAN model.
probaEff
The probability of efficacy estimated with STAN model.
p
The probability of success.
targetTox
The target of toxicity.
givenDose
The vector of doses given to patients so far.
Author(s)
Artemis Toumazi artemis.toumazi@gmail.com,
Caroline Petit caroline.petit@crc.jussieu.fr,
Sarah Zohar sarah.zohar@inserm.fr
References
Petit, C., et al, (2016) Unified approach for extrapolation and bridging of adult information in early phase dose-finding paediatric studies, Statistical Methods in Medical Research, <doi:10.1177/0962280216671348>.
Examples
1
2
3
4
5
6
7
r <- 0.10
q <- 0.17
p <- 0.9
targetTox <- 0.6
givenDose <- 2
newDose <- doseChoice(r, q, p, targetTox, givenDose)
newDose
dfped documentation built on May 2, 2019, 8:36 a.m.
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Description Usage Arguments Author(s) References Examples
Description
Algorithm giving the next dose which is the safe most successful dose (sMSD).
Usage
1 | doseChoice(probaTox, probaEff, p, targetTox, givenDose)
|
Arguments
probaTox |
The probability of toxicity estimated with STAN model. |
probaEff |
The probability of efficacy estimated with STAN model. |
p |
The probability of success. |
targetTox |
The target of toxicity. |
givenDose |
The vector of doses given to patients so far. |
Author(s)
Artemis Toumazi artemis.toumazi@gmail.com, Caroline Petit caroline.petit@crc.jussieu.fr, Sarah Zohar sarah.zohar@inserm.fr
References
Petit, C., et al, (2016) Unified approach for extrapolation and bridging of adult information in early phase dose-finding paediatric studies, Statistical Methods in Medical Research, <doi:10.1177/0962280216671348>.
Examples
1 2 3 4 5 6 7 | r <- 0.10
q <- 0.17
p <- 0.9
targetTox <- 0.6
givenDose <- 2
newDose <- doseChoice(r, q, p, targetTox, givenDose)
newDose
|
R Package Documentation
Browse R Packages
We want your feedback!
Note that we can't provide technical support on individual packages. You should contact the package authors for that.
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