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An S4 class containg input parameters and results for reconstructed haplotype-blocks
An S4 class containing a SNP_time_series data object, the haplotype-blocks were
constructed on, parameters that were used for haplotype-block reconstruction and results
of haplotype block reconstruction. An hbr object can only be created with
reconstruct_hb.
datA SNP_time_series object containg the time series data and threshold used for
marker filtering (refer to SNP_time_series for more details)
chromosomeThe chromosome for which haplotype-blocks were calculated.
min.cl.sizeNumeric specifying the minimum number of correlated markers in a window for haplotype-block reconstruction
min.cl.corNumeric specifying the correlation between marker SNPs required using average linkage clustering for markers to be assembled in one cluster
min.interNumeric specifying the minimum number of markers in two clusters of overlapping windows required to be identical for cluster elongation across windows to build haplotype-blocks
single.winBoolean specifying that are supported by only a cluster in one window are also included in the markers of reconstructed blocks. If FALSE only hbrs are returned that span at least two windows and only markers being present in the intersection between overlapping windows are included.
transfBoolean indicating if time series data was sqrt transformed prior to clustering.
scaleSNPBoolean indicating if time series data was scaled (mean=0, var=1) for each SNP prior to clustering.
pos.corBoolean indicating if negative correletions between time series between two SNPs were set to zero prior to clustering.
cl.chrA list containing results from clustering of low frequency markers in the
experimental starting population for each window. Each list element contains the results
for a window.If clusters for the respective window were identified the respective list
numeric vectors with the marker positions for each cluster. If no clusters were identified
the list is empty. The clusters identified for overlapping windows are the basis for
cluster elongation to haplotype-blocks as present in cl.long.m.
cl.long.mA list containing the results of haplotype-bock reconstruction. Each
list element corresponds to a reconstructed #' haplotype-block and contains a numeric
vector with all the SNP positions. The minor allele in the experimnental starting
population at those positions represent marker alleles for the respective hapltotype-block.
Chromosome-wide haplotype-blocks can be visualized with plot.
Susanne U. Franssen
Franssen, Barton & Schloetterer 2016, Reconstruction of haplotype-blocks selected during experimental evolution, MBE
ex_dat summary.hbr plot.hbr
plot_cluster_trajectories plot_marker_trajectories
map rev_map markers plot_hbr_freq
inspect_window inspect_window_PCA inspect_window_avLink
inspect_window_dbScan number_hbr
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