gen_serum_creatinine: Generate serum creatinine values for a virtual population.

In httk: High-Throughput Toxicokinetics

Generate serum creatinine values for a virtual population.

Description

Predict serum creatinine from age using smoothing splines and kernel density estimates of residual variability fitted to NHANES data,, for a given combination of gender and NHANES race/ethnicity category.

Usage

gen_serum_creatinine(gender, reth, age_years, age_months, nhanes_mec_svy)

Arguments

gender	Gender for which to generate serum creatinine values ("Male" or "Female")
reth	NHANES race/ethnicity category for which to generate serum creatinine values ("Mexican American", "Non-Hispanic Black", "Non-Hispanic White", "Other", or "Other Hispanic")
age_years	Vector of ages in years for individuals for whom to generate serum creatinine values (corresponding to age_months)
age_months	vector of ages in months for individuals for whom to generate serum creatinine values (between 0-959 months)
nhanes_mec_svy	surveydesign object created from mecdt using svydesign (this is done in httkpop_generate)

Details

This function should usually not be called directly by the user. It is used by httkpop_generate() in "virtual-individuals" mode, after drawing gender, NHANES race/ethnicity category, and age from their NHANES proportions/distributions.

Value

A vector of numeric generated serum creatinine values (mg/dL).

Author(s)

Caroline Ring

References

Ring, Caroline L., et al. "Identifying populations sensitive to environmental chemicals by simulating toxicokinetic variability." Environment International 106 (2017): 105-118

httk documentation built on March 7, 2023, 7:26 p.m.