mcnally_dt: Reference tissue masses and flows from tables in McNally et...

In httk: High-Throughput Toxicokinetics

Reference tissue masses and flows from tables in McNally et al. 2014.

Description

Reference tissue masses, flows, and residual variance distributions from Tables 1, 4, and 5 of McNally et al. 2014.

Usage

mcnally_dt

Format

A data.table with variables:

tissue

Body tissue

gender

Gender: Male or Female

mass_ref

Reference mass in kg, from Reference Man

mass_cv

Coefficient of variation for mass

mass_dist

Distribution for mass: Normal or Log-normal

flow_ref

Reference flow in L/h, from Reference Man

flow_cv

Coefficient of variation for flow (all normally distributed)

height_ref

Reference heights (by gender)

CO_ref

Reference cardiac output by gender

flow_frac

Fraction of CO flowing to each tissue: flow_ref/CO_ref

Author(s)

Caroline Ring

Source

McNally K, Cotton R, Hogg A, Loizou G. "PopGen: A virtual human population generator." Toxicology 315, 70-85, 2004.

References

Ring, Caroline L., et al. "Identifying populations sensitive to environmental chemicals by simulating toxicokinetic variability." Environment International 106 (2017): 105-118

httk documentation built on March 7, 2023, 7:26 p.m.