parameterize_kramer: Parameterize Kramer IVD Model
In httk: High-Throughput Toxicokinetics

parameterize_kramer

R Documentation

Parameterize Kramer IVD Model

Description

This function takes inputs from kramer_eval() and calls parameterize_IVD(). Converts units and sets up variables for kramer_eval().

Usage

parameterize_kramer(
  tcdata = NA,
  casrn.vector = NA_character_,
  this.FBSf = NA_real_,
  this.BSA = 44,
  this.v_total = NA_real_,
  this.v_working = NA_real_,
  this.cell_yield = NA_real_,
  this.sarea = NA_real_,
  this.prot_conc = 0.21
)

Arguments

`tcdata`	A data table with well_number corresponding to plate format, optionally include v_working, sarea, option.bottom, and option.plastic
`casrn.vector`	A deprecated argument specifying a single or vector of Chemical Abstracts Service Registry Number(s) (CAS-RN) of desired chemical(s).
`this.FBSf`	Fraction fetal bovine serum
`this.BSA`	bovine serum albumin concentration (g/L)
`this.v_total`	Total volume per well (uL)
`this.v_working`	Working volume per well (uL)
`this.cell_yield`	Number of cells/well seeded
`this.sarea`	Surface area per well (m^2)
`this.prot_conc`	Cell protein concentration (mg protein/million cells)

Value

A data table composed of any input data.table tcdata with only the following columns either created or altered by this function:

Column Name	Description	Units
sarea	surface area	m^2
v_working_m3	working (filled) volume of each well	m^3
v_total_m3	total volume of each well	m^3
v_headspace_m3	volume of headspace per well	m^3
conc_BSA	BSA concentration in media	kg/L
FBSp	Percent fetal bovine serum in media	percent
conc_cell_mg	concentration of cell lipids	mg/m^3
conc_cell	concentration of cell lipids	kg/m^3
conc_plastic	concentration of plastic	m2/m^3