pfas.clearance | R Documentation |
If the chemical- and species-specific TK half-life (t_{1/2}
) and volume of
distribution (V_{d}
) are known, a whole-body plasma clearance rate can be
calculated as:
Cl_{tot} = ln(1/2) / t_{1/2} * V_{d}
The first term involving the natural logarithm of 1/2 converts half-life (h)
into an elimination rate (1/h) so that Cl_{tot}
has units of
L/kg bodyweight/h.
Dawson et al. (2023) reported a table of in vivo PFAS t_{1/2}
data for multiple
species across eleven PFAS. Most of the measured data are for rodents. These
data result from a series of reviews of the literature by
Lau et al. (most recently Fenton et al. 2021) that were further revised for
Dawson et al. (2023).
Dawson et al. (2023) Supplemental Information S2.5 compiled V_{d}
values that
were used here for calculating total clearance. A dataset of
literature-derived values of V_{d}
was compiled starting from
Pizzurro et al. (2019) Table 2, which compiled 38 observations spanning
five PFAS chemicals, four species, and both sexes from various literature
sources. To these we added 24 calculated V_{d}
observations in rat for three
chemicals across a range of doses and routes from Huang et al. (2019).
Further values for V_{d}
were collected from the peer-review literature
(Dzierlenga et al. 2020; Lau et al. 2020; Lou et al. 2009; Tatum-Gibbs et al. 2011).
The total data set includes 128 values for V_{d}
from 8 PFAS chemicals
across 4 species.
A Cl_{tot}
was calculated using the above equation for every chemical- and
species-specific half-life reported in the
Dawson et al. (2023) supplemental materials. For chemicals without
species- and compound-specific measurements for V_{d}
we used the median
in vivo measured PFAS Vd of 0.205 L/kg BW.
pfas.clearance
data.frame
The data.frame contains the following columns:
Column Name | Description |
DTXSID | CompTox Chemicals Dashboard substance identifier |
Species | Species for which the clearance was calculated |
Sex | Sex for which the clearance was calculated |
HalfLifeHours | Half-life in hours |
HlReference | Reference(s) for half-life |
VdLpkgbw | Volume of distribution in L/kg body weight |
VdReference | Reference for volume of distribution |
Kelimph | Elimination rate in 1/hour |
ClLphpkgbw | Total clearance in L/h/kg body weight |
dawson2023machinehttk
\insertReffenton2021perhttk
\insertRefpizzurro2019interspecieshttk
\insertRefhuang2019toxicokineticshttk
\insertRefdzierlenga2020toxicokineticshttk
\insertReflau2020pharmacokinetichttk
\insertReflou2009modelinghttk
\insertReftatum2011comparativehttk
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