NEWS.md

In ncappc: NCA Calculations and Population Model Diagnosis

ncappc 1.0.0

• This is a major release (to version 1.0.0), since the package is in a stable state and is not considered experimental anymore.

• Created a webpage for the package using pkgdown. See https://uupharmacometrics.github.io/ncappc/

• Updated which time and concentration values are used for extrapolation for lamda_z when interpolation occurs (#5).

• Updated tidyverse functions that have been depreciated.

• Removed the Cairo package from the dependencies of this package.

ncappc 0.3.0

• New mean and variance of NCA metrics histogram plots

• Updating how reports are generated and standardizing how they appear

• Change how estimate_nca works, making tidy calculations the default and assuring that that the same function works for both real and simulated data

• Added parallel computation of NCA metrics for simulated data

• Added a number of automatic tests used for checking the package including results from ncappc publication.

• Added a NEWS.md file to track changes to the package.

• Fixed depencies between ggplot2, grid and scales

• Updated vignettes

• More examples added to documentation

• Allowing extrapolation for fewer than three points in the elimination phase of a profile

• Allow timing messages to be turned on and off.

• Bug fixes

• linear-log option was changed to linearup-logdown

• Central tendency measure for NCA metrics changed from mean to median

• Updated documentation

• Changed package maintainer

• MRTINF pitfall fixed

• Added continuous integration

• Made onlyNCA work as it should

ncappc documentation built on June 8, 2025, 12:55 p.m.